Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism

Nikita Roy; Robert J. Barry; Francesca E. Fernandez; Chai K. Lim; Mahmoud A. Al‑Dabbas; Diana Karamacoska; Samantha J. Broyd; Nadia Solowij; Christine L. Chiu; Genevieve Z. Steiner

doi:10.1038/s41598-020-74780-9

Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism

Nikita Roy, Robert J. Barry, Francesca E. Fernandez, Chai K. Lim, Mahmoud A. Al‑Dabbas, Diana Karamacoska, Samantha J. Broyd, Nadia Solowij, Christine L. Chiu, Genevieve Z. Steiner

Western Sydney University

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The brain-derived neurotrophic factor (BDNF) protein is essential for neuronal development. Val66Met (rs6265) is a functional polymorphism at codon 66 of the BDNF gene that affects neuroplasticity and has been associated with cognition, brain structure and function. The aim of this study was to clarify the relationship between BDNF Val66Met polymorphism and neuronal oscillatory activity, using the electroencephalogram (EEG), in a normative cohort. Neurotypical (N = 92) young adults were genotyped for the BDNF Val66Met polymorphism and had eyes open resting-state EEG recorded for four minutes. Focal increases in right fronto-parietal delta, and decreases in alpha-1 and right hemispheric alpha-2 amplitudes were observed for the Met/Met genotype group compared to Val/Val and Val/Met groups. Stronger frontal topographies were demonstrated for beta-1 and beta-2 in the Val/Met group versus the Val/Val group. Findings highlight BDNF Val66Met genotypic differences in EEG spectral amplitudes, with increased cortical excitability implications for Met allele carriers.

Original language	English
Article number	17915
Number of pages	11
Journal	Scientific Reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41598-020-74780-9
Publication status	Published - 2020

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Keywords

genetic polymorphisms
neurotrophic functions

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10.1038/s41598-020-74780-9

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title = "Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism",

abstract = "The brain-derived neurotrophic factor (BDNF) protein is essential for neuronal development. Val66Met (rs6265) is a functional polymorphism at codon 66 of the BDNF gene that affects neuroplasticity and has been associated with cognition, brain structure and function. The aim of this study was to clarify the relationship between BDNF Val66Met polymorphism and neuronal oscillatory activity, using the electroencephalogram (EEG), in a normative cohort. Neurotypical (N = 92) young adults were genotyped for the BDNF Val66Met polymorphism and had eyes open resting-state EEG recorded for four minutes. Focal increases in right fronto-parietal delta, and decreases in alpha-1 and right hemispheric alpha-2 amplitudes were observed for the Met/Met genotype group compared to Val/Val and Val/Met groups. Stronger frontal topographies were demonstrated for beta-1 and beta-2 in the Val/Met group versus the Val/Val group. Findings highlight BDNF Val66Met genotypic differences in EEG spectral amplitudes, with increased cortical excitability implications for Met allele carriers.",

keywords = "genetic polymorphisms, neurotrophic functions",

author = "Nikita Roy and Barry, {Robert J.} and Fernandez, {Francesca E.} and Lim, {Chai K.} and Al‑Dabbas, {Mahmoud A.} and Diana Karamacoska and Broyd, {Samantha J.} and Nadia Solowij and Chiu, {Christine L.} and Steiner, {Genevieve Z.}",

year = "2020",

doi = "10.1038/s41598-020-74780-9",

language = "English",

volume = "10",

journal = "Scientific Reports",

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T1 - Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism

AU - Roy, Nikita

AU - Barry, Robert J.

AU - Fernandez, Francesca E.

AU - Lim, Chai K.

AU - Al‑Dabbas, Mahmoud A.

AU - Karamacoska, Diana

AU - Broyd, Samantha J.

AU - Solowij, Nadia

AU - Chiu, Christine L.

AU - Steiner, Genevieve Z.

PY - 2020

Y1 - 2020

N2 - The brain-derived neurotrophic factor (BDNF) protein is essential for neuronal development. Val66Met (rs6265) is a functional polymorphism at codon 66 of the BDNF gene that affects neuroplasticity and has been associated with cognition, brain structure and function. The aim of this study was to clarify the relationship between BDNF Val66Met polymorphism and neuronal oscillatory activity, using the electroencephalogram (EEG), in a normative cohort. Neurotypical (N = 92) young adults were genotyped for the BDNF Val66Met polymorphism and had eyes open resting-state EEG recorded for four minutes. Focal increases in right fronto-parietal delta, and decreases in alpha-1 and right hemispheric alpha-2 amplitudes were observed for the Met/Met genotype group compared to Val/Val and Val/Met groups. Stronger frontal topographies were demonstrated for beta-1 and beta-2 in the Val/Met group versus the Val/Val group. Findings highlight BDNF Val66Met genotypic differences in EEG spectral amplitudes, with increased cortical excitability implications for Met allele carriers.

AB - The brain-derived neurotrophic factor (BDNF) protein is essential for neuronal development. Val66Met (rs6265) is a functional polymorphism at codon 66 of the BDNF gene that affects neuroplasticity and has been associated with cognition, brain structure and function. The aim of this study was to clarify the relationship between BDNF Val66Met polymorphism and neuronal oscillatory activity, using the electroencephalogram (EEG), in a normative cohort. Neurotypical (N = 92) young adults were genotyped for the BDNF Val66Met polymorphism and had eyes open resting-state EEG recorded for four minutes. Focal increases in right fronto-parietal delta, and decreases in alpha-1 and right hemispheric alpha-2 amplitudes were observed for the Met/Met genotype group compared to Val/Val and Val/Met groups. Stronger frontal topographies were demonstrated for beta-1 and beta-2 in the Val/Met group versus the Val/Val group. Findings highlight BDNF Val66Met genotypic differences in EEG spectral amplitudes, with increased cortical excitability implications for Met allele carriers.

KW - genetic polymorphisms

KW - neurotrophic functions

UR - https://hdl.handle.net/1959.7/uws:58842

U2 - 10.1038/s41598-020-74780-9

DO - 10.1038/s41598-020-74780-9

M3 - Article

VL - 10

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 17915

ER -

Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism

Abstract

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