Elevated maternal plasma immunoreactive phospholipase A2 in human preterm and term labour

G. E. Rice; S. P. Brennecke; K. F. Scott; G. M. Smith; I. A. Rajkovic; G. J. Bishop

Elevated maternal plasma immunoreactive phospholipase A₂ in human preterm and term labour

G. E. Rice, S. P. Brennecke, K. F. Scott, G. M. Smith, I. A. Rajkovic, G. J. Bishop

Monash University

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Peripheral plasma concentrations of immunoreactive phospholipase A₂ (irPLA₂) (Type II, non-pancreatic) were determined in 110 women during pregnancy. The concentration of irPLA₂ did not significantly change during pregnancy (5.7 ± 0.6 ng/ml, n = 72) until the onset of labour. When compared with non-labouring women, irPLA₂ concentrations were significantly elevated in association with both preterm labour (13.3 ± 2.4 ng/ml, n = 15, p < 0.02) and labour at term (10.4 ± 1.7, n = 23, p < 0.02). These data suggest that maternal plasma irPLA₂ may be reflective of the mechanism(s) underlying the labour-associated increase in human gestational tissue eicosanoid formation.

Original language	English
Pages (from-to)	9-12
Number of pages	4
Journal	Eicosanoids
Volume	5
Issue number	1
Publication status	Published - 1992
Externally published	Yes

Cite this

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title = "Elevated maternal plasma immunoreactive phospholipase A2 in human preterm and term labour",

abstract = "Peripheral plasma concentrations of immunoreactive phospholipase A2 (irPLA2) (Type II, non-pancreatic) were determined in 110 women during pregnancy. The concentration of irPLA2 did not significantly change during pregnancy (5.7 ± 0.6 ng/ml, n = 72) until the onset of labour. When compared with non-labouring women, irPLA2 concentrations were significantly elevated in association with both preterm labour (13.3 ± 2.4 ng/ml, n = 15, p < 0.02) and labour at term (10.4 ± 1.7, n = 23, p < 0.02). These data suggest that maternal plasma irPLA2 may be reflective of the mechanism(s) underlying the labour-associated increase in human gestational tissue eicosanoid formation.",

author = "Rice, {G. E.} and Brennecke, {S. P.} and Scott, {K. F.} and Smith, {G. M.} and Rajkovic, {I. A.} and Bishop, {G. J.}",

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T1 - Elevated maternal plasma immunoreactive phospholipase A2 in human preterm and term labour

AU - Rice, G. E.

AU - Brennecke, S. P.

AU - Scott, K. F.

AU - Smith, G. M.

AU - Rajkovic, I. A.

AU - Bishop, G. J.

PY - 1992

Y1 - 1992

N2 - Peripheral plasma concentrations of immunoreactive phospholipase A2 (irPLA2) (Type II, non-pancreatic) were determined in 110 women during pregnancy. The concentration of irPLA2 did not significantly change during pregnancy (5.7 ± 0.6 ng/ml, n = 72) until the onset of labour. When compared with non-labouring women, irPLA2 concentrations were significantly elevated in association with both preterm labour (13.3 ± 2.4 ng/ml, n = 15, p < 0.02) and labour at term (10.4 ± 1.7, n = 23, p < 0.02). These data suggest that maternal plasma irPLA2 may be reflective of the mechanism(s) underlying the labour-associated increase in human gestational tissue eicosanoid formation.

AB - Peripheral plasma concentrations of immunoreactive phospholipase A2 (irPLA2) (Type II, non-pancreatic) were determined in 110 women during pregnancy. The concentration of irPLA2 did not significantly change during pregnancy (5.7 ± 0.6 ng/ml, n = 72) until the onset of labour. When compared with non-labouring women, irPLA2 concentrations were significantly elevated in association with both preterm labour (13.3 ± 2.4 ng/ml, n = 15, p < 0.02) and labour at term (10.4 ± 1.7, n = 23, p < 0.02). These data suggest that maternal plasma irPLA2 may be reflective of the mechanism(s) underlying the labour-associated increase in human gestational tissue eicosanoid formation.

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Elevated maternal plasma immunoreactive phospholipase A₂ in human preterm and term labour

Abstract

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