TY - JOUR
T1 - Elevated parathyroid hormone predicts high asymmetric dimethylarginine (ADMA) concentrations in obese diabetic patients
AU - Amarasekera, A. T.
AU - Sverdlov, A. L.
AU - Horowitz, J. D.
AU - Ngo, D. T.
PY - 2016
Y1 - 2016
N2 - Impaired vascular endothelial function has been suggested as a possible mechanism to explain the nexus between vitamin D deficiency and increased adverse cardiovascular outcomes. In addition, elevated PTH is also found associated with increased arterial stiffness and impaired endothelial function, improved after lowering of PTH with parathyroidectomy. Previously, we have shown that in an ageing population, low vitamin D levels are associated with elevated plasma concentrations of asymmetric dimethylarginine (ADMA). Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelial nitric oxide synthase (eNOS), has been shown to be a critical circulating biomarker of endothelial function, and adverse cardiovascular outcomes. However, we did not assess the relationship between ADMA and PTH. Given, the high prevalence of low vitamin D and high parathyroid hormone (PTH) levels in obese diabetic patients, we sought to examine in this study, whether the relationship between ADMA and vitamin D is independent of PTH levels in obese diabetic.
AB - Impaired vascular endothelial function has been suggested as a possible mechanism to explain the nexus between vitamin D deficiency and increased adverse cardiovascular outcomes. In addition, elevated PTH is also found associated with increased arterial stiffness and impaired endothelial function, improved after lowering of PTH with parathyroidectomy. Previously, we have shown that in an ageing population, low vitamin D levels are associated with elevated plasma concentrations of asymmetric dimethylarginine (ADMA). Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelial nitric oxide synthase (eNOS), has been shown to be a critical circulating biomarker of endothelial function, and adverse cardiovascular outcomes. However, we did not assess the relationship between ADMA and PTH. Given, the high prevalence of low vitamin D and high parathyroid hormone (PTH) levels in obese diabetic patients, we sought to examine in this study, whether the relationship between ADMA and vitamin D is independent of PTH levels in obese diabetic.
KW - cardiovascular system
KW - diabetics
KW - obesity
KW - parathyroid hormone
KW - vitamin D
UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:41745
U2 - 10.1016/j.diabet.2016.05.002
DO - 10.1016/j.diabet.2016.05.002
M3 - Article
SN - 1262-3636
VL - 42
SP - 378
EP - 381
JO - Diabetes and Metabolism
JF - Diabetes and Metabolism
IS - 5
ER -