Elevated parathyroid hormone predicts high asymmetric dimethylarginine (ADMA) concentrations in obese diabetic patients

A. T. Amarasekera, A. L. Sverdlov, J. D. Horowitz, D. T. Ngo

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Impaired vascular endothelial function has been suggested as a possible mechanism to explain the nexus between vitamin D deficiency and increased adverse cardiovascular outcomes. In addition, elevated PTH is also found associated with increased arterial stiffness and impaired endothelial function, improved after lowering of PTH with parathyroidectomy. Previously, we have shown that in an ageing population, low vitamin D levels are associated with elevated plasma concentrations of asymmetric dimethylarginine (ADMA). Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelial nitric oxide synthase (eNOS), has been shown to be a critical circulating biomarker of endothelial function, and adverse cardiovascular outcomes. However, we did not assess the relationship between ADMA and PTH. Given, the high prevalence of low vitamin D and high parathyroid hormone (PTH) levels in obese diabetic patients, we sought to examine in this study, whether the relationship between ADMA and vitamin D is independent of PTH levels in obese diabetic.
Original languageEnglish
Pages (from-to)378-381
Number of pages4
JournalDiabetes and Metabolism
Volume42
Issue number5
DOIs
Publication statusPublished - 2016

Keywords

  • cardiovascular system
  • diabetics
  • obesity
  • parathyroid hormone
  • vitamin D

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