TY - JOUR
T1 - Endocytosis of G protein-coupled receptors and their ligands : is there a role in metal trafficking?
AU - Christofides, Katerina
AU - Menon, Resmi
AU - Jones, Christopher E.
PY - 2018
Y1 - 2018
N2 - The prevalence of metal dysregulation in many neurodegenerative and neurocognitive disorders has compelled many studying such diseases to investigate the mechanisms underlying metal regulation in the central nervous system. Metal homoeostasis is often complex, with sophisticated, multilayered pathways in operation. G protein-coupled receptors are omnipresent on cell membranes and have intriguing mechanisms of endocytosis and trafficking that may be useful in metal homoeostasis. Indeed, many receptors and/or their cognate ligands are able to bind metals, and in many cases metals are considered to have neuromodulatory roles as a result of receptor binding. In this mini-review, we outline the structural and functional aspects of G protein-coupled receptors with a focus on the mechanisms leading to endocytosis and cellular trafficking. We further highlight how this may help in the trafficking of metal ions, notably copper.
AB - The prevalence of metal dysregulation in many neurodegenerative and neurocognitive disorders has compelled many studying such diseases to investigate the mechanisms underlying metal regulation in the central nervous system. Metal homoeostasis is often complex, with sophisticated, multilayered pathways in operation. G protein-coupled receptors are omnipresent on cell membranes and have intriguing mechanisms of endocytosis and trafficking that may be useful in metal homoeostasis. Indeed, many receptors and/or their cognate ligands are able to bind metals, and in many cases metals are considered to have neuromodulatory roles as a result of receptor binding. In this mini-review, we outline the structural and functional aspects of G protein-coupled receptors with a focus on the mechanisms leading to endocytosis and cellular trafficking. We further highlight how this may help in the trafficking of metal ions, notably copper.
KW - copper
KW - endocytosis
KW - metabolism
KW - metals
KW - neurochemistry
UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:47631
U2 - 10.1007/s12013-018-0850-9
DO - 10.1007/s12013-018-0850-9
M3 - Article
SN - 1559-0283
SN - 1085-9195
VL - 76
SP - 329
EP - 337
JO - Cell Biochemistry and Biophysics
JF - Cell Biochemistry and Biophysics
IS - 3
ER -