TY - JOUR
T1 - Engineering exosome-based biomimetic nanovehicles for wound healing
AU - Joorabloo, A.
AU - Liu, Tianqing
PY - 2023/4
Y1 - 2023/4
N2 - Complexity and difficulties in wound management are pressing concerns that affect patients' quality of life and may result in tissue infection, necrosis, and loss of local and systemic functions. Hence, novel approaches to accelerate wound healing are being actively explored over the last decade. Exosomes as important mediators of intercellular communications are promising natural nanocarriers due to their biocompatibility, low immunogenicity, drug loading and targeting capacities, and innate stability. More importantly, exosomes are developed as a versatile pharmaceutical engineering platform for wound repair. This review provides an overview of the biological and physiological functions of exosomes derived from a variety of biological origins during wound healing phases, strategies for exosomal engineering, and therapeutic applications in skin regeneration.
AB - Complexity and difficulties in wound management are pressing concerns that affect patients' quality of life and may result in tissue infection, necrosis, and loss of local and systemic functions. Hence, novel approaches to accelerate wound healing are being actively explored over the last decade. Exosomes as important mediators of intercellular communications are promising natural nanocarriers due to their biocompatibility, low immunogenicity, drug loading and targeting capacities, and innate stability. More importantly, exosomes are developed as a versatile pharmaceutical engineering platform for wound repair. This review provides an overview of the biological and physiological functions of exosomes derived from a variety of biological origins during wound healing phases, strategies for exosomal engineering, and therapeutic applications in skin regeneration.
UR - https://hdl.handle.net/1959.7/uws:75830
U2 - 10.1016/j.jconrel.2023.03.013
DO - 10.1016/j.jconrel.2023.03.013
M3 - Article
SN - 1873-4995
SN - 0168-3659
VL - 356
SP - 463
EP - 480
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -