Engineering exosome-based biomimetic nanovehicles for wound healing

A. Joorabloo, Tianqing Liu

Research output: Contribution to journalArticlepeer-review

Abstract

Complexity and difficulties in wound management are pressing concerns that affect patients' quality of life and may result in tissue infection, necrosis, and loss of local and systemic functions. Hence, novel approaches to accelerate wound healing are being actively explored over the last decade. Exosomes as important mediators of intercellular communications are promising natural nanocarriers due to their biocompatibility, low immunogenicity, drug loading and targeting capacities, and innate stability. More importantly, exosomes are developed as a versatile pharmaceutical engineering platform for wound repair. This review provides an overview of the biological and physiological functions of exosomes derived from a variety of biological origins during wound healing phases, strategies for exosomal engineering, and therapeutic applications in skin regeneration.
Original languageEnglish
Pages (from-to)463-480
Number of pages18
JournalJournal of Controlled Release
Volume356
DOIs
Publication statusPublished - Apr 2023

Open Access - Access Right Statement

© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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