Engineering exosome-based biomimetic nanovehicles for wound healing

A. Joorabloo; Tianqing Liu

doi:10.1016/j.jconrel.2023.03.013

Engineering exosome-based biomimetic nanovehicles for wound healing

A. Joorabloo, Tianqing Liu

Western Sydney University

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Complexity and difficulties in wound management are pressing concerns that affect patients' quality of life and may result in tissue infection, necrosis, and loss of local and systemic functions. Hence, novel approaches to accelerate wound healing are being actively explored over the last decade. Exosomes as important mediators of intercellular communications are promising natural nanocarriers due to their biocompatibility, low immunogenicity, drug loading and targeting capacities, and innate stability. More importantly, exosomes are developed as a versatile pharmaceutical engineering platform for wound repair. This review provides an overview of the biological and physiological functions of exosomes derived from a variety of biological origins during wound healing phases, strategies for exosomal engineering, and therapeutic applications in skin regeneration.

Original language	English
Pages (from-to)	463-480
Number of pages	18
Journal	Journal of Controlled Release
Volume	356
DOIs	https://doi.org/10.1016/j.jconrel.2023.03.013
Publication status	Published - Apr 2023

Bibliographical note

Publisher Copyright:
© 2023

Open Access - Access Right Statement

Access to Document

10.1016/j.jconrel.2023.03.013Licence: CC BY

Full textFinal published version, 10.2 MBLicence: CC BY

Cite this

@article{0860a28ddadf417595f2dab8f3cc909d,

title = "Engineering exosome-based biomimetic nanovehicles for wound healing",

abstract = "Complexity and difficulties in wound management are pressing concerns that affect patients' quality of life and may result in tissue infection, necrosis, and loss of local and systemic functions. Hence, novel approaches to accelerate wound healing are being actively explored over the last decade. Exosomes as important mediators of intercellular communications are promising natural nanocarriers due to their biocompatibility, low immunogenicity, drug loading and targeting capacities, and innate stability. More importantly, exosomes are developed as a versatile pharmaceutical engineering platform for wound repair. This review provides an overview of the biological and physiological functions of exosomes derived from a variety of biological origins during wound healing phases, strategies for exosomal engineering, and therapeutic applications in skin regeneration.",

author = "A. Joorabloo and Tianqing Liu",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = apr,

doi = "10.1016/j.jconrel.2023.03.013",

language = "English",

volume = "356",

pages = "463--480",

journal = "Journal of Controlled Release",

issn = "0168-3659",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Engineering exosome-based biomimetic nanovehicles for wound healing

AU - Joorabloo, A.

AU - Liu, Tianqing

PY - 2023/4

Y1 - 2023/4

N2 - Complexity and difficulties in wound management are pressing concerns that affect patients' quality of life and may result in tissue infection, necrosis, and loss of local and systemic functions. Hence, novel approaches to accelerate wound healing are being actively explored over the last decade. Exosomes as important mediators of intercellular communications are promising natural nanocarriers due to their biocompatibility, low immunogenicity, drug loading and targeting capacities, and innate stability. More importantly, exosomes are developed as a versatile pharmaceutical engineering platform for wound repair. This review provides an overview of the biological and physiological functions of exosomes derived from a variety of biological origins during wound healing phases, strategies for exosomal engineering, and therapeutic applications in skin regeneration.

AB - Complexity and difficulties in wound management are pressing concerns that affect patients' quality of life and may result in tissue infection, necrosis, and loss of local and systemic functions. Hence, novel approaches to accelerate wound healing are being actively explored over the last decade. Exosomes as important mediators of intercellular communications are promising natural nanocarriers due to their biocompatibility, low immunogenicity, drug loading and targeting capacities, and innate stability. More importantly, exosomes are developed as a versatile pharmaceutical engineering platform for wound repair. This review provides an overview of the biological and physiological functions of exosomes derived from a variety of biological origins during wound healing phases, strategies for exosomal engineering, and therapeutic applications in skin regeneration.

UR - https://hdl.handle.net/1959.7/uws:75830

UR - http://www.scopus.com/inward/record.url?scp=85150036207&partnerID=8YFLogxK

U2 - 10.1016/j.jconrel.2023.03.013

DO - 10.1016/j.jconrel.2023.03.013

M3 - Article

C2 - 36907562

SN - 0168-3659

VL - 356

SP - 463

EP - 480

JO - Journal of Controlled Release

JF - Journal of Controlled Release

ER -

Engineering exosome-based biomimetic nanovehicles for wound healing

Abstract

Bibliographical note

Open Access - Access Right Statement

Access to Document

Other files and links

Fingerprint

Cite this