Escitalopram efficacy in depression : a cross-ethnicity examination of the serotonin transporter promoter polymorphism

Chad A. Bousman; Jerome Sarris; Eun-Soo Won; Hun-Soo Chang; Ajeet Singh; Hwa-Young Lee; Byung-Joo Ham; Chay-Hoon Tan; Min-Soo Lee; Chee H. Ng

doi:10.1097/JCP.0000000000000165

Escitalopram efficacy in depression : a cross-ethnicity examination of the serotonin transporter promoter polymorphism

Chad A. Bousman, Jerome Sarris, Eun-Soo Won, Hun-Soo Chang, Ajeet Singh, Hwa-Young Lee, Byung-Joo Ham, Chay-Hoon Tan, Min-Soo Lee, Chee H. Ng

Western Sydney University

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner.

Original language	English
Pages (from-to)	645-648
Number of pages	4
Journal	Journal of Clinical Psychopharmacology
Volume	34
Issue number	5
DOIs	https://doi.org/10.1097/JCP.0000000000000165
Publication status	Published - 2014

Keywords

antidepressants
depression_mental
ethnicity
genotype
pharmacogenetics
serotonin

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10.1097/JCP.0000000000000165

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abstract = "Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner.",

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T1 - Escitalopram efficacy in depression : a cross-ethnicity examination of the serotonin transporter promoter polymorphism

AU - Bousman, Chad A.

AU - Sarris, Jerome

AU - Won, Eun-Soo

AU - Chang, Hun-Soo

AU - Singh, Ajeet

AU - Lee, Hwa-Young

AU - Ham, Byung-Joo

AU - Tan, Chay-Hoon

AU - Lee, Min-Soo

AU - Ng, Chee H.

PY - 2014

Y1 - 2014

N2 - Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner.

AB - Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner.

KW - antidepressants

KW - depression_mental

KW - ethnicity

KW - genotype

KW - pharmacogenetics

KW - serotonin

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:39619

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DO - 10.1097/JCP.0000000000000165

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JO - Journal of Clinical Psychopharmacology

JF - Journal of Clinical Psychopharmacology

IS - 5

ER -

Escitalopram efficacy in depression : a cross-ethnicity examination of the serotonin transporter promoter polymorphism

Abstract

Keywords

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