Estimated human absorbed dose of 177Lu-BPAMD based on mice data: Comparison with 177Lu-EDTMP

Hassan Yousefnia; Samaneh Zolghadri; Saeed Shanehsazzadeh

doi:10.1016/j.apradiso.2015.06.033

Estimated human absorbed dose of 177Lu-BPAMD based on mice data: Comparison with 177Lu-EDTMP

Hassan Yousefnia
, Samaneh Zolghadri
, Saeed Shanehsazzadeh

Nuclear Science and Technology Research Institute, Tehran

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

In this work, the absorbed dose of human organs for Lu-177-BPAMD was evaluated based on biodistribution studies into the Syrian mice by RADAR method and was compared with Lu-177-EDTMP as the only clinically used Lu-177 bone-seeking agent. The highest absorbed dose for both Lu-177-BPAMD and Lu-177-EDTMP is observed on the bone surface with 8.007 and 4.802 mSv/MBq. Generally, Lu-177-BPAMD has considerable characteristics compared with Lu-177-EDTMP and can be considered as a promising agent for the bone pain palliation therapy.

Original language	English
Pages (from-to)	128-135
Number of pages	8
Journal	Applied Radiation and Isotopes
Volume	104
DOIs	https://doi.org/10.1016/j.apradiso.2015.06.033
Publication status	Published - Oct 2015
Externally published	Yes

Access to Document

10.1016/j.apradiso.2015.06.033

Cite this

@article{91bc68517feb44ba9d7c095769addaac,

title = "Estimated human absorbed dose of 177Lu-BPAMD based on mice data: Comparison with 177Lu-EDTMP",

abstract = "In this work, the absorbed dose of human organs for Lu-177-BPAMD was evaluated based on biodistribution studies into the Syrian mice by RADAR method and was compared with Lu-177-EDTMP as the only clinically used Lu-177 bone-seeking agent. The highest absorbed dose for both Lu-177-BPAMD and Lu-177-EDTMP is observed on the bone surface with 8.007 and 4.802 mSv/MBq. Generally, Lu-177-BPAMD has considerable characteristics compared with Lu-177-EDTMP and can be considered as a promising agent for the bone pain palliation therapy.",

author = "Hassan Yousefnia and Samaneh Zolghadri and Saeed Shanehsazzadeh",

year = "2015",

month = oct,

doi = "10.1016/j.apradiso.2015.06.033",

language = "English",

volume = "104",

pages = "128--135",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier",

}

TY - JOUR

T1 - Estimated human absorbed dose of 177Lu-BPAMD based on mice data: Comparison with 177Lu-EDTMP

AU - Yousefnia, Hassan

AU - Zolghadri, Samaneh

AU - Shanehsazzadeh, Saeed

PY - 2015/10

Y1 - 2015/10

N2 - In this work, the absorbed dose of human organs for Lu-177-BPAMD was evaluated based on biodistribution studies into the Syrian mice by RADAR method and was compared with Lu-177-EDTMP as the only clinically used Lu-177 bone-seeking agent. The highest absorbed dose for both Lu-177-BPAMD and Lu-177-EDTMP is observed on the bone surface with 8.007 and 4.802 mSv/MBq. Generally, Lu-177-BPAMD has considerable characteristics compared with Lu-177-EDTMP and can be considered as a promising agent for the bone pain palliation therapy.

AB - In this work, the absorbed dose of human organs for Lu-177-BPAMD was evaluated based on biodistribution studies into the Syrian mice by RADAR method and was compared with Lu-177-EDTMP as the only clinically used Lu-177 bone-seeking agent. The highest absorbed dose for both Lu-177-BPAMD and Lu-177-EDTMP is observed on the bone surface with 8.007 and 4.802 mSv/MBq. Generally, Lu-177-BPAMD has considerable characteristics compared with Lu-177-EDTMP and can be considered as a promising agent for the bone pain palliation therapy.

UR - https://go.openathens.net/redirector/westernsydney.edu.au?url=https://doi.org/ 10.1016/j.apradiso.2015.06.033

U2 - 10.1016/j.apradiso.2015.06.033

DO - 10.1016/j.apradiso.2015.06.033

M3 - Article

SN - 0969-8043

VL - 104

SP - 128

EP - 135

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

ER -

Estimated human absorbed dose of 177Lu-BPAMD based on mice data: Comparison with 177Lu-EDTMP

Abstract

Access to Document

Other files and links

Fingerprint

Cite this