TY - JOUR
T1 - Estimation of human effective absorbed dose of 67Ga-cDTPA-gonadorelin based on biodistribution rat data
AU - Shanehsazzadeh, S.
AU - Lahooti, Afsaneh
AU - Sadeghi, H. R.
AU - Jalilian, A. R.
PY - 2011
Y1 - 2011
N2 - OBJECTIVE: In this investigation, we estimated the effective absorbed dose of radiation into human organs, after an intravenous administration of gallium-67 (Ga)-labeled gonadorelin, one of the gonadotropin-releasing hormone (GnRH) agonists, using biodistribution data from injected normal rats. METHODS: Five rats were killed at exact time intervals (0.25, 0.5, 1, 2, 4, 24, and 48 h post injections) and the percentage of injected dose per gram of each organ was measured by direct counting from rat data. The Medical Internal Radiation Dose formulation was applied to extrapolate from rat to human and to project the absorbed radiation dose for various organs in humans. RESULTS: From rat data we estimated that a 185-MBq injection of Ga-cDTPA-GnRH into the humans might result in an estimated absorbed dose of 5.26 mGy in the whole body with the highest effective absorbed dose was in the lungs (2.73 mSv), and the organs that received the next highest doses were the bladder wall (1.59 mSv), liver (0.80 mSv), and bone marrow (0.52 mSv). CONCLUSION: The biodistribution of Ga-cDTPA-GnRH in rats showed high breast uptake and low muscle and blood uptake. These results suggest that it should be possible to perform early imaging of the breast anomalies and GnRH receptors indicating potential malignant lesions.
AB - OBJECTIVE: In this investigation, we estimated the effective absorbed dose of radiation into human organs, after an intravenous administration of gallium-67 (Ga)-labeled gonadorelin, one of the gonadotropin-releasing hormone (GnRH) agonists, using biodistribution data from injected normal rats. METHODS: Five rats were killed at exact time intervals (0.25, 0.5, 1, 2, 4, 24, and 48 h post injections) and the percentage of injected dose per gram of each organ was measured by direct counting from rat data. The Medical Internal Radiation Dose formulation was applied to extrapolate from rat to human and to project the absorbed radiation dose for various organs in humans. RESULTS: From rat data we estimated that a 185-MBq injection of Ga-cDTPA-GnRH into the humans might result in an estimated absorbed dose of 5.26 mGy in the whole body with the highest effective absorbed dose was in the lungs (2.73 mSv), and the organs that received the next highest doses were the bladder wall (1.59 mSv), liver (0.80 mSv), and bone marrow (0.52 mSv). CONCLUSION: The biodistribution of Ga-cDTPA-GnRH in rats showed high breast uptake and low muscle and blood uptake. These results suggest that it should be possible to perform early imaging of the breast anomalies and GnRH receptors indicating potential malignant lesions.
UR - https://hdl.handle.net/1959.7/uws:76384
U2 - 10.1097/MNM.0b013e328340b916
DO - 10.1097/MNM.0b013e328340b916
M3 - Article
SN - 0143-3636
VL - 32
SP - 37
EP - 43
JO - Nuclear Medicine Communications
JF - Nuclear Medicine Communications
IS - 1
ER -