Euonymus alatus : a review on its phytochemistry and antidiabetic activity

Xifeng Zhai; George Binh Lenon; Charlie C. L. Xue; Chun-Guang Li

doi:10.1155/2016/9425714

Euonymus alatus : a review on its phytochemistry and antidiabetic activity

Xifeng Zhai, George Binh Lenon, Charlie C. L. Xue, Chun-Guang Li

Western Sydney University

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Euonymus alatus (E. alatus) is a medicinal plant used in some Asian countries for treating various conditions including cancer, hyperglycemia, and diabetic complications. This review outlines the phytochemistry and bioactivities of E. alatus related to antidiabetic actions. More than 100 chemical constituents have been isolated and identified from E. alatus, including flavonoids, terpenoids, steroids, lignans, cardenolides, phenolic acids, and alkaloids. Studies in vitro and in vivo have demonstrated the hypoglycemic activity of E. alatus extracts and its certain constituents. The hypoglycemic activity of E. alatus may be related to regulation of insulin signaling and insulin sensitivity, involving PPAR𝛾 and aldose reductase pathways. Further studies on E. alatus and its bioactive compounds may help to develop new agents for treating diabetes and diabetic complications.

Original language	English
Article number	9425714
Number of pages	12
Journal	Evidence-Based Complementary and Alternative Medicine
Volume	2016
DOIs	https://doi.org/10.1155/2016/9425714
Publication status	Published - 2016

Open Access - Access Right Statement

Copyright © 2016 Xifeng Zhai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

medicinal plants
hypoglycemic agents

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10.1155/2016/9425714

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abstract = "Euonymus alatus (E. alatus) is a medicinal plant used in some Asian countries for treating various conditions including cancer, hyperglycemia, and diabetic complications. This review outlines the phytochemistry and bioactivities of E. alatus related to antidiabetic actions. More than 100 chemical constituents have been isolated and identified from E. alatus, including flavonoids, terpenoids, steroids, lignans, cardenolides, phenolic acids, and alkaloids. Studies in vitro and in vivo have demonstrated the hypoglycemic activity of E. alatus extracts and its certain constituents. The hypoglycemic activity of E. alatus may be related to regulation of insulin signaling and insulin sensitivity, involving PPAR𝛾 and aldose reductase pathways. Further studies on E. alatus and its bioactive compounds may help to develop new agents for treating diabetes and diabetic complications.",

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AU - Zhai, Xifeng

AU - Lenon, George Binh

AU - Xue, Charlie C. L.

AU - Li, Chun-Guang

PY - 2016

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KW - hypoglycemic agents

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DO - 10.1155/2016/9425714

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SN - 1741-427X

VL - 2016

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ER -

Euonymus alatus : a review on its phytochemistry and antidiabetic activity

Abstract

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Keywords

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