Abstract
![CDATA[Background: The Diabetes REmission Clinical Trial (DiRECT) study demonstrated that a program including intensive structured total diet replacement (TDR) in UK primary care resulted in high rates of diabetes remission in adults with recent onset type 2 diabetes (T2DM). This study aimed to assess the effectiveness of implementing the DiRECT intervention within a primary care setting in Australia. Methods: Participants were all patients enrolled in the DiRECT-Australia T2DM Remission Service in South Western Sydney, aged 20-70 years, non-insulin treated, with T2DM duration ≤6 years, and body mass index (BMI) ≥27kg/m². The intervention comprised an 800 Kcal/day TDR program for 12 weeks, having withdrawn glucose-lowering medications at baseline, followed by a structured ongoing support until 52 weeks, with regular follow-up with general practitioner, practice nurse, and/or dietitian. Data were collected at baseline, 12 weeks, and 52 weeks including QoL measures. Results: Of 39 participants recruited, 32 (82.1%) completed the 12-week TDR, and 27 (69.2%) provided 52-week data. Mean weight loss was 12.0 kg (95% CI: -9.6, -14.4, p<0.001) at 12 weeks and 9.1 kg (95% CI: -5.2, -12.9, p<0.001) at 52 weeks. HbA1c dropped by -1.1% (95% CI: -0.6 to -1.6, p<0.001) at 12 weeks and -0.6% (95% CI: -0.1 to -1.1, p=0.013) at 52 weeks. At the end of 12 and 52 weeks, 93.8% and 63.0% of participants remained off glucose-lowering medications, and 93.8% and 55.6% achieved diabetes remission, respectively. Sustained improvements in quality of life and wellbeing were observed at 12 and 52 weeks, as indicated by increases in EQ-5D Utility Index, EQ-5D VAS, and WHO-5 Well-being Index measures (p<0.001). Conclusions: These results support the feasibility of a structured diabetes remission intervention within the Australian context, and can inform the development of a framework for effective delivery of a structured diabetes remission service in Australian primary care.]]
Original language | English |
---|---|
Title of host publication | Australasian Diabetes Congress 2023, 23-25 August 2023, Adelaide Convention Centre, South Australia |
Publisher | Australian Diabetes Society |
Number of pages | 1 |
Publication status | Published - 2023 |
Event | Australasian Diabetes Congress - Duration: 1 Jan 2023 → … |
Conference
Conference | Australasian Diabetes Congress |
---|---|
Period | 1/01/23 → … |