Abstract
A commonly observed limitation of conducting hydrogenations under flow chemistry conditions is hydrodehalogenation. In a bid to circumvent this limitation a series of hydrogenation catalysts were screened, with 5% Pt/C (sulfided) catalyst identified as an effective catalyst to selectively effect reductive aminations, nitro reduction, and alkene reductions in the presence of halogen atoms. Additionally the optimised protocol cleanly reduced imines in the presence of a furan moiety indicating potential amenability to other labile functionalities.
Original language | English |
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Pages (from-to) | 56743-56748 |
Number of pages | 6 |
Journal | RSC Advances: an international journal to further the chemical sciences |
Volume | 4 |
Issue number | 100 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- hydrogenation
- nitro reduction
- reductive aminations
- robust protocol