Experiments to detect long-range heteronuclear shift correlations: LR-J-HSMQC

A. M. Torres; W. A. Bubb; P. W. Kuchel

doi:10.1006/jmre.2002.2563

Experiments to detect long-range heteronuclear shift correlations: LR-J-HSMQC

A. M. Torres
, W. A. Bubb
, P. W. Kuchel

The University of Sydney

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The utility of the J-HSMQC experiment to detect long-range CH correlations was investigated. Two new long-range J-compensated pulse sequences, LR-J-HSMQC(80,27) and LR-J-HSMQC(27,80), were developed using the (3β_x)β_y composite 90° pulse sequence. These two experiments were shown to be effective for long-range coupling constants, ⁿJ_CH, that were greater than 3 Hz. Although the overall sensitivities of the long-range J-HSMQC experiments were slightly lower than that of the conventional decoupled HMBC experiment, their 2D maps showed additional cross peaks that could be useful in structure elucidation. LR-J-HSMQC(27,80) was very efficient in yielding two- and four-bond relay correlations. The utility of the new sequences is demonstrated with strychnine as the sample.

Original language	English
Pages (from-to)	249-257
Number of pages	9
Journal	Journal of Magnetic Resonance
Volume	156
Issue number	2
DOIs	https://doi.org/10.1006/jmre.2002.2563
Publication status	Published - 2002
Externally published	Yes

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title = "Experiments to detect long-range heteronuclear shift correlations: LR-J-HSMQC",

abstract = "The utility of the J-HSMQC experiment to detect long-range CH correlations was investigated. Two new long-range J-compensated pulse sequences, LR-J-HSMQC(80,27) and LR-J-HSMQC(27,80), were developed using the (3βx)βy composite 90° pulse sequence. These two experiments were shown to be effective for long-range coupling constants, nJCH, that were greater than 3 Hz. Although the overall sensitivities of the long-range J-HSMQC experiments were slightly lower than that of the conventional decoupled HMBC experiment, their 2D maps showed additional cross peaks that could be useful in structure elucidation. LR-J-HSMQC(27,80) was very efficient in yielding two- and four-bond relay correlations. The utility of the new sequences is demonstrated with strychnine as the sample.",

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AU - Bubb, W. A.

AU - Kuchel, P. W.

PY - 2002

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AB - The utility of the J-HSMQC experiment to detect long-range CH correlations was investigated. Two new long-range J-compensated pulse sequences, LR-J-HSMQC(80,27) and LR-J-HSMQC(27,80), were developed using the (3βx)βy composite 90° pulse sequence. These two experiments were shown to be effective for long-range coupling constants, nJCH, that were greater than 3 Hz. Although the overall sensitivities of the long-range J-HSMQC experiments were slightly lower than that of the conventional decoupled HMBC experiment, their 2D maps showed additional cross peaks that could be useful in structure elucidation. LR-J-HSMQC(27,80) was very efficient in yielding two- and four-bond relay correlations. The utility of the new sequences is demonstrated with strychnine as the sample.

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DO - 10.1006/jmre.2002.2563

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ER -

Experiments to detect long-range heteronuclear shift correlations: LR-J-HSMQC

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