TY - JOUR
T1 - Exposure to ambient air pollution and risk of childhood cancers
T2 - A population-based study in Tehran, Iran
AU - Seifi, Morteza
AU - Niazi, Sadegh
AU - Johnson, Graham
AU - Nodehi, Vahideh
AU - Yunesian, Masud
PY - 2019
Y1 - 2019
N2 - The relationship between air pollution and childhood cancer is inconclusive. We investigated the associations between exposure to ambient air pollution and childhood cancers in Tehran, Iran. This project included children between 1 and 15"¯years-of-age with a cancer diagnosis by the Center for the Control of Non Communicable Disease (n"¯="¯161) during 2007 to 2009. Controls were selected randomly within the city using a Geographic Information System (GIS) (n"¯="¯761). The cases were geocoded based on exact home addresses. Air pollution exposure of cases and random controls were estimated by a previously developed Land Use Regression (LUR) model for the 2010 calendar year. The annual mean concentrations of Particulate Matter"¯â‰¤"¯10"¯Î¼m (PM10), nitrogen dioxide (NO2) and sulfur dioxide (SO2) in the locations of cancer cases were 101.97"¯Î¼g/m3, 49.42"¯ppb and 38.92"¯ppb respectively, while in the random control group, respective mean exposures were 98.63"¯Î¼g/m3, 45.98"¯ppb and 38.95"¯ppb. A logistic regression model was used to find the probability of childhood cancer per unit increase in PM10, NO2 and SO2. We observed a positive association between exposures to PM10 with childhood cancers. We did, however, observe a positive, but not statistically significant association between NO2 exposure and childhood cancer. Our study is the first to highlight an association between air pollution exposure and childhood cancer risk in Iran, however these findings require replication through future studies.
AB - The relationship between air pollution and childhood cancer is inconclusive. We investigated the associations between exposure to ambient air pollution and childhood cancers in Tehran, Iran. This project included children between 1 and 15"¯years-of-age with a cancer diagnosis by the Center for the Control of Non Communicable Disease (n"¯="¯161) during 2007 to 2009. Controls were selected randomly within the city using a Geographic Information System (GIS) (n"¯="¯761). The cases were geocoded based on exact home addresses. Air pollution exposure of cases and random controls were estimated by a previously developed Land Use Regression (LUR) model for the 2010 calendar year. The annual mean concentrations of Particulate Matter"¯â‰¤"¯10"¯Î¼m (PM10), nitrogen dioxide (NO2) and sulfur dioxide (SO2) in the locations of cancer cases were 101.97"¯Î¼g/m3, 49.42"¯ppb and 38.92"¯ppb respectively, while in the random control group, respective mean exposures were 98.63"¯Î¼g/m3, 45.98"¯ppb and 38.95"¯ppb. A logistic regression model was used to find the probability of childhood cancer per unit increase in PM10, NO2 and SO2. We observed a positive association between exposures to PM10 with childhood cancers. We did, however, observe a positive, but not statistically significant association between NO2 exposure and childhood cancer. Our study is the first to highlight an association between air pollution exposure and childhood cancer risk in Iran, however these findings require replication through future studies.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-85050305759&partnerID=MN8TOARS
UR - https://ezproxy.uws.edu.au/login?url=https://doi.org/10.1016/j.scitotenv.2018.07.219
U2 - 10.1016/j.scitotenv.2018.07.219
DO - 10.1016/j.scitotenv.2018.07.219
M3 - Article
SN - 0048-9697
VL - 646
SP - 105
EP - 110
JO - Science of the Total Environment
JF - Science of the Total Environment
ER -
