TY - JOUR
T1 - Factors associated with inflamm-aging in institutionalized older people
AU - Oliveira Neto, Leônidas de
AU - Tavares, Vagner Deuel de O.
AU - Agrícola, Pedro Moraes Dutra
AU - Oliveira, Larissa Praça de
AU - Sales, Márcia Cristina
AU - Sena-Evangelista, Karine Cavalcanti Maurício de
AU - Gomes, Igor Conterato
AU - Galvão-Coelho, Nicole Leite
AU - Pedrosa, Lúcia Fátima Campos
AU - Lima, Kenio Costa
PY - 2021
Y1 - 2021
N2 - The increase in inflammatory cytokines associated with a reduction in the bioavailability of zinc has been used as a marker for inflammation. Despite the high inflammatory state found in institutionalized older individuals, few studies have proposed verifying the factors associated with this condition in this population. To verify the factors associated with inflamm-aging in institutionalized older people. A total of 178 older people (≥ 60Â years old) living in nursing homes in Natal/RN were included in the study. Cluster analysis was used to identify three groups according to their inflammatory state. Analysis anthropometric, biochemical, sociodemographic, and health-related variables was carried out. In sequence, an ordinal logistic regression was performed for a confidence level of 95% in those variables with p < 0.20 in the bivariate analysis. IL-6, TNF-α, zinc, low-density lipids (LDL), high-density lipids (HDL), and triglycerides were associated with inflamm-aging. The increase of 1 unit of measurement of LDL, HDL, and triglycerides increased the chance of inflammation-aging by 1.5%, 4.1%, and 0.9%, respectively, while the oldest old (≥ 80Â years old) had an 84.9% chance of presenting inflamm-aging in relation to non-long-lived older people (< 80Â years). The association between biochemical markers and inflamm-aging demonstrates a relationship between endothelial injury and the inflammatory state. In addition, the presence of a greater amount of fat in the blood may present a higher relative risk of death.
AB - The increase in inflammatory cytokines associated with a reduction in the bioavailability of zinc has been used as a marker for inflammation. Despite the high inflammatory state found in institutionalized older individuals, few studies have proposed verifying the factors associated with this condition in this population. To verify the factors associated with inflamm-aging in institutionalized older people. A total of 178 older people (≥ 60Â years old) living in nursing homes in Natal/RN were included in the study. Cluster analysis was used to identify three groups according to their inflammatory state. Analysis anthropometric, biochemical, sociodemographic, and health-related variables was carried out. In sequence, an ordinal logistic regression was performed for a confidence level of 95% in those variables with p < 0.20 in the bivariate analysis. IL-6, TNF-α, zinc, low-density lipids (LDL), high-density lipids (HDL), and triglycerides were associated with inflamm-aging. The increase of 1 unit of measurement of LDL, HDL, and triglycerides increased the chance of inflammation-aging by 1.5%, 4.1%, and 0.9%, respectively, while the oldest old (≥ 80Â years old) had an 84.9% chance of presenting inflamm-aging in relation to non-long-lived older people (< 80Â years). The association between biochemical markers and inflamm-aging demonstrates a relationship between endothelial injury and the inflammatory state. In addition, the presence of a greater amount of fat in the blood may present a higher relative risk of death.
UR - https://hdl.handle.net/1959.7/uws:65615
U2 - 10.1038/s41598-021-97225-3
DO - 10.1038/s41598-021-97225-3
M3 - Article
SN - 2045-2322
VL - 11
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 18333
ER -