TY - JOUR
T1 - Factors underlying cognitive decline in old age and Alzheimer's disease : the role of the hippocampus
AU - Jaroudi, Wafa
AU - Garami, Julia
AU - Garrido, Sandra
AU - Hornberger, Michael
AU - Keri, Szabolcs
AU - Moustafa, Ahmed A.
PY - 2017
Y1 - 2017
N2 - There are many factors that strongly influence the aetiology, development, and progression of cognitive decline in old age, mild cognitive impairment (MCI), and Alzheimer's disease (AD). These factors include not only different personality traits and moods but also lifestyle patterns (e.g. exercise and diet) and awareness levels that lead to cognitive decline in old age. In this review, we discuss how personality traits, mood states, and lifestyle impact brain and behaviour in older adults. Specifically, our review shows that these lifestyle and personality factors affect several brain regions, including the hippocampus, a region key for memory that is affected by cognitive decline in old age as well as AD. Accordingly, appropriate recommendations are presented in this review to assist individuals in decreasing chances of MCI, dementia, AD, and associated symptoms.
AB - There are many factors that strongly influence the aetiology, development, and progression of cognitive decline in old age, mild cognitive impairment (MCI), and Alzheimer's disease (AD). These factors include not only different personality traits and moods but also lifestyle patterns (e.g. exercise and diet) and awareness levels that lead to cognitive decline in old age. In this review, we discuss how personality traits, mood states, and lifestyle impact brain and behaviour in older adults. Specifically, our review shows that these lifestyle and personality factors affect several brain regions, including the hippocampus, a region key for memory that is affected by cognitive decline in old age as well as AD. Accordingly, appropriate recommendations are presented in this review to assist individuals in decreasing chances of MCI, dementia, AD, and associated symptoms.
KW - Alzheimer's disease
KW - affective disorders
KW - cognition in old age
KW - dementia
KW - hippocampus (brain)
KW - personality
UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:44214
U2 - 10.1515/revneuro-2016-0086
DO - 10.1515/revneuro-2016-0086
M3 - Article
SN - 0334-1763
VL - 28
SP - 705
EP - 714
JO - Reviews in the Neurosciences
JF - Reviews in the Neurosciences
IS - 7
ER -