Failure of daptomycin Î²-Lactam combination therapy to prevent resistance emergence in Enterococcus faecium

Vidthiya Menon; Rebecca Davis; Nick Shackel; Bjorn A. Espedido; Alicia G. Beukers; Slade O. Jensen; Sebastiaan J. van Hal

doi:10.1016/j.diagmicrobio.2017.10.017

Failure of daptomycin Î²-Lactam combination therapy to prevent resistance emergence in Enterococcus faecium

Vidthiya Menon
, Rebecca Davis
, Nick Shackel
, Bjorn A. Espedido
, Alicia G. Beukers
, Slade O. Jensen
, Sebastiaan J. van Hal

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Daptomycin Î²-Lactam combination therapy offers "protection" against daptomycin non-susceptibility (DNS) development in Enterococcus faecium. We report failure of this strategy and the importance of source control. Mutations were detected in the LiaF and cls genes in DNS isolates. A single DNS isolate contained an unrecognized mutation, which requires confirmation.

Original language	English
Pages (from-to)	120-122
Number of pages	3
Journal	Diagnostic Microbiology and Infectious Disease
Volume	90
Issue number	2
DOIs	https://doi.org/10.1016/j.diagmicrobio.2017.10.017
Publication status	Published - Feb 2018

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Inc.

Keywords

drug resistance in microorganisms
enterococcus

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10.1016/j.diagmicrobio.2017.10.017

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title = "Failure of daptomycin {\^I}²-Lactam combination therapy to prevent resistance emergence in Enterococcus faecium",

abstract = "Daptomycin {\^I}²-Lactam combination therapy offers {"}protection{"} against daptomycin non-susceptibility (DNS) development in Enterococcus faecium. We report failure of this strategy and the importance of source control. Mutations were detected in the LiaF and cls genes in DNS isolates. A single DNS isolate contained an unrecognized mutation, which requires confirmation.",

keywords = "drug resistance in microorganisms, enterococcus",

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note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2018",

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doi = "10.1016/j.diagmicrobio.2017.10.017",

language = "English",

volume = "90",

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journal = "Diagnostic Microbiology and Infectious Disease",

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T1 - Failure of daptomycin Î²-Lactam combination therapy to prevent resistance emergence in Enterococcus faecium

AU - Menon, Vidthiya

AU - Davis, Rebecca

AU - Shackel, Nick

AU - Espedido, Bjorn A.

AU - Beukers, Alicia G.

AU - Jensen, Slade O.

AU - van Hal, Sebastiaan J.

PY - 2018/2

Y1 - 2018/2

N2 - Daptomycin Î²-Lactam combination therapy offers "protection" against daptomycin non-susceptibility (DNS) development in Enterococcus faecium. We report failure of this strategy and the importance of source control. Mutations were detected in the LiaF and cls genes in DNS isolates. A single DNS isolate contained an unrecognized mutation, which requires confirmation.

AB - Daptomycin Î²-Lactam combination therapy offers "protection" against daptomycin non-susceptibility (DNS) development in Enterococcus faecium. We report failure of this strategy and the importance of source control. Mutations were detected in the LiaF and cls genes in DNS isolates. A single DNS isolate contained an unrecognized mutation, which requires confirmation.

KW - drug resistance in microorganisms

KW - enterococcus

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:44823

U2 - 10.1016/j.diagmicrobio.2017.10.017

DO - 10.1016/j.diagmicrobio.2017.10.017

M3 - Article

C2 - 29195768

SN - 1879-0070

SN - 0732-8893

VL - 90

SP - 120

EP - 122

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 2

ER -

Failure of daptomycin Î²-Lactam combination therapy to prevent resistance emergence in Enterococcus faecium

Abstract

Bibliographical note

Keywords

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