Fever-range temperature modulates activation and function of human dendritic cells stimulated with the pathogenic mould Aspergillus fumigatus

Anna Semmlinger, Mirjam Fliesser, Ana Maria Waaga-Gasser, Mariola Dragan, C. Oliver Morton, Hermann Einsele, Juergen Loeffler

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    11 Citations (Scopus)

    Abstract

    In immunocompromised patients, invasive aspergillosis (IA) is the most frequent disease caused by the pathogenic mould Aspergillus fumigatus. Fever is one of the most common yet nonspecific clinical symptoms of IA. To evaluate the role of hyperthermia in the innate immune response to A. fumigatus in vitro, human monocyte-derived dendritic cells (DCs) were stimulated with germ tubes of A. fumigatus or the fungal cell wall component zymosan at 37◦C or 40◦C, followed by characterization of specific DC functions. While maturation of DCs was enhanced and DC phagocytic capacity was reduced at 40◦C, we observed that DC viability and cytokine release were unaffected. Thus, our results suggest that hyperthermia has substantial impacts on DC function in vitro, which might also influence the course and outcome of IA in immunocompromised patients.
    Original languageEnglish
    Pages (from-to)438-444
    Number of pages7
    JournalMedical Mycology
    Volume52
    Issue number4
    DOIs
    Publication statusPublished - 2014

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