TY - JOUR
T1 - Fijimycins A–C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp.
AU - Sun, Peng
AU - Maloney, Katherine N.
AU - Nam, Sang-Jip
AU - Haste, Nina M.
AU - Raju, Ritesh
AU - Aalbersberg, William
AU - Jensen, Paul R.
AU - Nizet, Victor
AU - Hensler, Mary E.
AU - Fenical, William
PY - 2011
Y1 - 2011
N2 - Three new depsipeptides, fijimycins A-C (1-3), together with the known etamycin A (4), were isolated and identified from the fermentation broth of strain CNS-575, a Streptomyces sp. cultured from a marine sediment sample collected off Nasese, Fiji. The planar structures of the new fijimycins were assigned by combined interpretation of NMR and MS/MS spectroscopic data. These assignments were complicated by the fact that 1-3 occurred as complex amide conformational mixtures. The absolute configurations of the component amino acids were established using the Marfey's method. Fijimycins A-C, and etamycin A, were shown to possess significant in vitro antibacterial activity against three methicillin-resistant Staphylococcus aureus (MRSA) strains with MIC100 values between 4 and 16 μg mL-1.
AB - Three new depsipeptides, fijimycins A-C (1-3), together with the known etamycin A (4), were isolated and identified from the fermentation broth of strain CNS-575, a Streptomyces sp. cultured from a marine sediment sample collected off Nasese, Fiji. The planar structures of the new fijimycins were assigned by combined interpretation of NMR and MS/MS spectroscopic data. These assignments were complicated by the fact that 1-3 occurred as complex amide conformational mixtures. The absolute configurations of the component amino acids were established using the Marfey's method. Fijimycins A-C, and etamycin A, were shown to possess significant in vitro antibacterial activity against three methicillin-resistant Staphylococcus aureus (MRSA) strains with MIC100 values between 4 and 16 μg mL-1.
UR - http://handle.uws.edu.au:8081/1959.7/547324
U2 - 10.1016/j.bmc.2011.06.053
DO - 10.1016/j.bmc.2011.06.053
M3 - Article
SN - 0968-0896
VL - 19
SP - 6557
EP - 6562
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 22
ER -
