Free propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses : a feasibility study on human mastectomies

S. Pacilè; C. Dullin; P. Baran; M. Tonutti; C. Perske; U. Fischer; J. Albers; F. Arfelli; D. Dreossi; K. Pavlov; A. Maksimenko; S. C. Mayo; Y. I. Nesterets; S. T. Taba; Sarah Lewis; P. C. Brennan; T. E. Gureyev; G. Tromba; S. Wienbeck

doi:10.1038/s41598-019-50075-6

Free propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses : a feasibility study on human mastectomies

S. Pacilè, C. Dullin, P. Baran, M. Tonutti, C. Perske, U. Fischer, J. Albers, F. Arfelli, D. Dreossi, K. Pavlov, A. Maksimenko, S. C. Mayo, Y. I. Nesterets, S. T. Taba, Sarah Lewis, P. C. Brennan, T. E. Gureyev, G. Tromba, S. Wienbeck

Western Sydney University

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

In this study we demonstrate the first direct comparison between synchrotron x-ray propagation-based CT (PB-CT) and cone-beam breast-CT (CB-CT) on human mastectomy specimens (N = 12) including different benign and malignant lesions. The image quality and diagnostic power of the obtained data sets were compared and judged by two independent expert radiologists. Two cases are presented in detail in this paper including a comparison with the corresponding histological evaluation. Results indicate that with PB-CT it is possible to increase the level of contrast-to-noise ratio (CNR) keeping the same level of dose used for the CB-CT or achieve the same level of CNR reached by CB-CT at a lower level of dose. In other words, PB-CT can achieve a higher diagnostic potential compared to the commercial breast-CT system while also delivering a considerably lower mean glandular dose. Therefore, we believe that PB-CT technique, if translated to a clinical setting, could have a significant impact in improving breast cancer diagnosis.

Original language	English
Article number	13762
Number of pages	7
Journal	Scientific Reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41598-019-50075-6
Publication status	Published - 2019

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Pacilè, S., Dullin, C., Baran, P., Tonutti, M., Perske, C., Fischer, U., Albers, J., Arfelli, F., Dreossi, D., Pavlov, K., Maksimenko, A., Mayo, S. C., Nesterets, Y. I., Taba, S. T., Lewis, S., Brennan, P. C., Gureyev, T. E., Tromba, G., & Wienbeck, S. (2019). Free propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses : a feasibility study on human mastectomies. Scientific Reports, 9(1), Article 13762. https://doi.org/10.1038/s41598-019-50075-6

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title = "Free propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses : a feasibility study on human mastectomies",

abstract = "In this study we demonstrate the first direct comparison between synchrotron x-ray propagation-based CT (PB-CT) and cone-beam breast-CT (CB-CT) on human mastectomy specimens (N = 12) including different benign and malignant lesions. The image quality and diagnostic power of the obtained data sets were compared and judged by two independent expert radiologists. Two cases are presented in detail in this paper including a comparison with the corresponding histological evaluation. Results indicate that with PB-CT it is possible to increase the level of contrast-to-noise ratio (CNR) keeping the same level of dose used for the CB-CT or achieve the same level of CNR reached by CB-CT at a lower level of dose. In other words, PB-CT can achieve a higher diagnostic potential compared to the commercial breast-CT system while also delivering a considerably lower mean glandular dose. Therefore, we believe that PB-CT technique, if translated to a clinical setting, could have a significant impact in improving breast cancer diagnosis.",

author = "S. Pacil{\`e} and C. Dullin and P. Baran and M. Tonutti and C. Perske and U. Fischer and J. Albers and F. Arfelli and D. Dreossi and K. Pavlov and A. Maksimenko and Mayo, {S. C.} and Nesterets, {Y. I.} and Taba, {S. T.} and Sarah Lewis and Brennan, {P. C.} and Gureyev, {T. E.} and G. Tromba and S. Wienbeck",

year = "2019",

doi = "10.1038/s41598-019-50075-6",

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Pacilè, S, Dullin, C, Baran, P, Tonutti, M, Perske, C, Fischer, U, Albers, J, Arfelli, F, Dreossi, D, Pavlov, K, Maksimenko, A, Mayo, SC, Nesterets, YI, Taba, ST, Lewis, S, Brennan, PC, Gureyev, TE, Tromba, G & Wienbeck, S 2019, 'Free propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses : a feasibility study on human mastectomies', Scientific Reports, vol. 9, no. 1, 13762. https://doi.org/10.1038/s41598-019-50075-6

TY - JOUR

T1 - Free propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses : a feasibility study on human mastectomies

AU - Pacilè, S.

AU - Dullin, C.

AU - Baran, P.

AU - Tonutti, M.

AU - Perske, C.

AU - Fischer, U.

AU - Albers, J.

AU - Arfelli, F.

AU - Dreossi, D.

AU - Pavlov, K.

AU - Maksimenko, A.

AU - Mayo, S. C.

AU - Nesterets, Y. I.

AU - Taba, S. T.

AU - Lewis, Sarah

AU - Brennan, P. C.

AU - Gureyev, T. E.

AU - Tromba, G.

AU - Wienbeck, S.

PY - 2019

Y1 - 2019

N2 - In this study we demonstrate the first direct comparison between synchrotron x-ray propagation-based CT (PB-CT) and cone-beam breast-CT (CB-CT) on human mastectomy specimens (N = 12) including different benign and malignant lesions. The image quality and diagnostic power of the obtained data sets were compared and judged by two independent expert radiologists. Two cases are presented in detail in this paper including a comparison with the corresponding histological evaluation. Results indicate that with PB-CT it is possible to increase the level of contrast-to-noise ratio (CNR) keeping the same level of dose used for the CB-CT or achieve the same level of CNR reached by CB-CT at a lower level of dose. In other words, PB-CT can achieve a higher diagnostic potential compared to the commercial breast-CT system while also delivering a considerably lower mean glandular dose. Therefore, we believe that PB-CT technique, if translated to a clinical setting, could have a significant impact in improving breast cancer diagnosis.

AB - In this study we demonstrate the first direct comparison between synchrotron x-ray propagation-based CT (PB-CT) and cone-beam breast-CT (CB-CT) on human mastectomy specimens (N = 12) including different benign and malignant lesions. The image quality and diagnostic power of the obtained data sets were compared and judged by two independent expert radiologists. Two cases are presented in detail in this paper including a comparison with the corresponding histological evaluation. Results indicate that with PB-CT it is possible to increase the level of contrast-to-noise ratio (CNR) keeping the same level of dose used for the CB-CT or achieve the same level of CNR reached by CB-CT at a lower level of dose. In other words, PB-CT can achieve a higher diagnostic potential compared to the commercial breast-CT system while also delivering a considerably lower mean glandular dose. Therefore, we believe that PB-CT technique, if translated to a clinical setting, could have a significant impact in improving breast cancer diagnosis.

UR - https://hdl.handle.net/1959.7/uws:74521

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IS - 1

M1 - 13762

ER -

Free propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses : a feasibility study on human mastectomies

Abstract

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