Free radicals, lipids and protein degradation

Simon P. Wolff; Anthony Garner; Roger T. Dean

doi:10.1016/0968-0004(86)90228-8

Free radicals, lipids and protein degradation

Simon P. Wolff
, Anthony Garner
, Roger T. Dean

Brunel University London

Research output: Contribution to journal › Article › peer-review

493 Citations (Scopus)

Abstract

Primary oxygen radicals produced in cells and their secondary lipid radical intermediates can modify and fragment proteins. The products are often more susceptible to enzymatic hydrolysis and so radical fluxes may accelerate proteolysis inside and outside cells.

Original language	English
Pages (from-to)	27-31
Number of pages	5
Journal	Trends in Biochemical Sciences
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/0968-0004(86)90228-8
Publication status	Published - Jan 1986
Externally published	Yes

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title = "Free radicals, lipids and protein degradation",

abstract = "Primary oxygen radicals produced in cells and their secondary lipid radical intermediates can modify and fragment proteins. The products are often more susceptible to enzymatic hydrolysis and so radical fluxes may accelerate proteolysis inside and outside cells.",

author = "Wolff, \{Simon P.\} and Anthony Garner and Dean, \{Roger T.\}",

year = "1986",

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AU - Dean, Roger T.

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AB - Primary oxygen radicals produced in cells and their secondary lipid radical intermediates can modify and fragment proteins. The products are often more susceptible to enzymatic hydrolysis and so radical fluxes may accelerate proteolysis inside and outside cells.

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U2 - 10.1016/0968-0004(86)90228-8

DO - 10.1016/0968-0004(86)90228-8

M3 - Article

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SN - 0968-0004

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EP - 31

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 1

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Free radicals, lipids and protein degradation

Abstract

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