Futuristic senolytic drug incorporated nanomedicine therapy to treat osteoarthritis

Laxmi Akhileshwar Jha; Bhupendra Kumar; Saurav Kumar Jha; Keshav Raj Paudel

doi:10.2217/nnm-2023-0348

Futuristic senolytic drug incorporated nanomedicine therapy to treat osteoarthritis

Laxmi Akhileshwar Jha
, Bhupendra Kumar
, Saurav Kumar Jha
, Keshav Raj Paudel

Dr. A.P.J. Abdul Kalam Technical University
Indian Institute of Technology Kanpur
Centenary Institute
University of Technology Sydney

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Cellular senescence is a chronic state of cell cycle arrest caused by several stressors (internal and extrinsic stimuli), such as DNA damage, telomere shortening and oncogene activation. It is a complex biological phenomenon essential for several age-related disorders, as well as healthy aging and development. On the other hand, articular cartilage (AC) degeneration, alterations in the underlying subchondral bone and joint inflammation characterize osteoarthritis (OA).

Original language	English
Pages (from-to)	837-840
Number of pages	4
Journal	Nanomedicine
Volume	19
Issue number	10
DOIs	https://doi.org/10.2217/nnm-2023-0348
Publication status	Published - 2024
Externally published	Yes

Keywords

drug delivery
nanomedicine
osteoarthritis
senescence
senolytics

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10.2217/nnm-2023-0348

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abstract = "Cellular senescence is a chronic state of cell cycle arrest caused by several stressors (internal and extrinsic stimuli), such as DNA damage, telomere shortening and oncogene activation. It is a complex biological phenomenon essential for several age-related disorders, as well as healthy aging and development. On the other hand, articular cartilage (AC) degeneration, alterations in the underlying subchondral bone and joint inflammation characterize osteoarthritis (OA).",

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AU - Kumar, Bhupendra

AU - Jha, Saurav Kumar

AU - Paudel, Keshav Raj

PY - 2024

Y1 - 2024

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AB - Cellular senescence is a chronic state of cell cycle arrest caused by several stressors (internal and extrinsic stimuli), such as DNA damage, telomere shortening and oncogene activation. It is a complex biological phenomenon essential for several age-related disorders, as well as healthy aging and development. On the other hand, articular cartilage (AC) degeneration, alterations in the underlying subchondral bone and joint inflammation characterize osteoarthritis (OA).

KW - drug delivery

KW - nanomedicine

KW - osteoarthritis

KW - senescence

KW - senolytics

UR - https://www.scopus.com/pages/publications/85189375645

UR - https://go.openathens.net/redirector/westernsydney.edu.au?url=https://doi.org/10.2217/nnm-2023-0348

U2 - 10.2217/nnm-2023-0348

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M3 - Article

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JO - Nanomedicine

JF - Nanomedicine

IS - 10

ER -

Futuristic senolytic drug incorporated nanomedicine therapy to treat osteoarthritis

Abstract

Keywords

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