GABA gene expression is differentially expressed across the prefrontal cortex following sensitisation to methamphetamine

J. Cornish, J. Franklin, A. Goodchild, L. Parker, Travis Wearne

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: Psychotic disorders, such as schizophrenia, are characterized by prev- alent and persistent executive deficits that are believed to be the result of dysfunctional inhibitory gamma-aminobutyric acid (GABA) processing of the prefrontal cortex (PFC). Methamphetamine (METH) is a commonly used psychostimulant that can induce psychotic and cognitive symptoms that are indistinguishable to schizophrenia, suggesting that METH-induced psychosis may have a similar GABAergic profile of the PFC. As the PFC consists of multiple subregions, the aim of the current study was to investi- gate changes to GABA genetic expression in the prelimbic (PRL) and orbi- tofrontal (OFC) cortices of the PFC following METH sensitization.
Original languageEnglish
Pages (from-to)5-5
Number of pages1
JournalAustralian Psychologist
Volume53
Issue numberSuppl. 1
DOIs
Publication statusPublished - 2018

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