GABA gene expression is differentially expressed across the prefrontal cortex following sensitisation to methamphetamine

J. Cornish; J. Franklin; A. Goodchild; L. Parker; Travis Wearne

doi:10.1111/ap.12372

GABA gene expression is differentially expressed across the prefrontal cortex following sensitisation to methamphetamine

J. Cornish
, J. Franklin
, A. Goodchild
, L. Parker
, Travis Wearne

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: Psychotic disorders, such as schizophrenia, are characterized by prev- alent and persistent executive deficits that are believed to be the result of dysfunctional inhibitory gamma-aminobutyric acid (GABA) processing of the prefrontal cortex (PFC). Methamphetamine (METH) is a commonly used psychostimulant that can induce psychotic and cognitive symptoms that are indistinguishable to schizophrenia, suggesting that METH-induced psychosis may have a similar GABAergic profile of the PFC. As the PFC consists of multiple subregions, the aim of the current study was to investi- gate changes to GABA genetic expression in the prelimbic (PRL) and orbi- tofrontal (OFC) cortices of the PFC following METH sensitization.

Original language	English
Pages (from-to)	5-5
Number of pages	1
Journal	Australian Psychologist
Volume	53
Issue number	Suppl. 1
DOIs	https://doi.org/10.1111/ap.12372
Publication status	Published - 2018

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10.1111/ap.12372

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title = "GABA gene expression is differentially expressed across the prefrontal cortex following sensitisation to methamphetamine",

abstract = "Aim: Psychotic disorders, such as schizophrenia, are characterized by prev- alent and persistent executive deficits that are believed to be the result of dysfunctional inhibitory gamma-aminobutyric acid (GABA) processing of the prefrontal cortex (PFC). Methamphetamine (METH) is a commonly used psychostimulant that can induce psychotic and cognitive symptoms that are indistinguishable to schizophrenia, suggesting that METH-induced psychosis may have a similar GABAergic profile of the PFC. As the PFC consists of multiple subregions, the aim of the current study was to investi- gate changes to GABA genetic expression in the prelimbic (PRL) and orbi- tofrontal (OFC) cortices of the PFC following METH sensitization.",

author = "J. Cornish and J. Franklin and A. Goodchild and L. Parker and Travis Wearne",

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AU - Cornish, J.

AU - Franklin, J.

AU - Goodchild, A.

AU - Parker, L.

AU - Wearne, Travis

PY - 2018

Y1 - 2018

N2 - Aim: Psychotic disorders, such as schizophrenia, are characterized by prev- alent and persistent executive deficits that are believed to be the result of dysfunctional inhibitory gamma-aminobutyric acid (GABA) processing of the prefrontal cortex (PFC). Methamphetamine (METH) is a commonly used psychostimulant that can induce psychotic and cognitive symptoms that are indistinguishable to schizophrenia, suggesting that METH-induced psychosis may have a similar GABAergic profile of the PFC. As the PFC consists of multiple subregions, the aim of the current study was to investi- gate changes to GABA genetic expression in the prelimbic (PRL) and orbi- tofrontal (OFC) cortices of the PFC following METH sensitization.

AB - Aim: Psychotic disorders, such as schizophrenia, are characterized by prev- alent and persistent executive deficits that are believed to be the result of dysfunctional inhibitory gamma-aminobutyric acid (GABA) processing of the prefrontal cortex (PFC). Methamphetamine (METH) is a commonly used psychostimulant that can induce psychotic and cognitive symptoms that are indistinguishable to schizophrenia, suggesting that METH-induced psychosis may have a similar GABAergic profile of the PFC. As the PFC consists of multiple subregions, the aim of the current study was to investi- gate changes to GABA genetic expression in the prelimbic (PRL) and orbi- tofrontal (OFC) cortices of the PFC following METH sensitization.

UR - https://hdl.handle.net/1959.7/uws:61078

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DO - 10.1111/ap.12372

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VL - 53

SP - 5

EP - 5

JO - Australian Psychologist

JF - Australian Psychologist

IS - Suppl. 1

ER -

GABA gene expression is differentially expressed across the prefrontal cortex following sensitisation to methamphetamine

Abstract

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