Gecko-inspired chitosan adhesive for tissue repair

Samuel J. Frost; Damia Mawad; Michael J. Higgins; Herleen Ruprai; Rhiannon Kuchel; Richard D. Tilley; Simon Myers; James M. Hook; Antonio Lauto

doi:10.1038/am.2016.73

Gecko-inspired chitosan adhesive for tissue repair

Samuel J. Frost, Damia Mawad, Michael J. Higgins, Herleen Ruprai, Rhiannon Kuchel, Richard D. Tilley, Simon Myers, James M. Hook, Antonio Lauto

Western Sydney University

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

The advent of nanotechnology has opened the possibility of fabricating nanoscopic pillars on the surface of polymeric films mimicking the Gecko’s foot, in an attempt to increase their adhesive capabilities enhanced by van der Waals forces. However, these forces are considerably weakened in a wet physiological environment. To circumvent this loss in force, currentbiocompatible adhesives with nanopillars require complex multiple-step fabrication, including an extra layer of adhesive coating to stabilize tissue bonding under physiological conditions. In this report, we describe a simple one-step fabrication process of a single-layer chitosan film that has pillars with base diameter in the range of 100–600 nm and a height of ̴70 nm. The nanostructured adhesive is laser-bonded to tissue and does not require pillar coating to enhance bonding in water. In comparison with a 'flat' adhesive (without pillars), the nanostructured adhesive bonded significantly stronger to tissue under either stress or pressure. Atomic force spectroscopy also confirmed the superior bonding capability of the nanostructured adhesive. This study demonstrates a one-step fabrication technique to produce a monolayer gecko-inspired adhesive that is biocompatible and bonds effectively to tissue.

Original language	English
Article number	e280
Number of pages	9
Journal	NPG Asia Materials
Volume	8
DOIs	https://doi.org/10.1038/am.2016.73
Publication status	Published - 2016

Open Access - Access Right Statement

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Keywords

nanotechnology
chitosan
adhesives

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10.1038/am.2016.73

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@article{8a8899697fff45818e92ae4498fec010,

title = "Gecko-inspired chitosan adhesive for tissue repair",

abstract = "The advent of nanotechnology has opened the possibility of fabricating nanoscopic pillars on the surface of polymeric films mimicking the Gecko{\textquoteright}s foot, in an attempt to increase their adhesive capabilities enhanced by van der Waals forces. However, these forces are considerably weakened in a wet physiological environment. To circumvent this loss in force, currentbiocompatible adhesives with nanopillars require complex multiple-step fabrication, including an extra layer of adhesive coating to stabilize tissue bonding under physiological conditions. In this report, we describe a simple one-step fabrication process of a single-layer chitosan film that has pillars with base diameter in the range of 100–600 nm and a height of ̴70 nm. The nanostructured adhesive is laser-bonded to tissue and does not require pillar coating to enhance bonding in water. In comparison with a 'flat' adhesive (without pillars), the nanostructured adhesive bonded significantly stronger to tissue under either stress or pressure. Atomic force spectroscopy also confirmed the superior bonding capability of the nanostructured adhesive. This study demonstrates a one-step fabrication technique to produce a monolayer gecko-inspired adhesive that is biocompatible and bonds effectively to tissue.",

keywords = "nanotechnology, chitosan, adhesives",

author = "Frost, {Samuel J.} and Damia Mawad and Higgins, {Michael J.} and Herleen Ruprai and Rhiannon Kuchel and Tilley, {Richard D.} and Simon Myers and Hook, {James M.} and Antonio Lauto",

year = "2016",

doi = "10.1038/am.2016.73",

language = "English",

volume = "8",

journal = "NPG Asia Materials",

issn = "1884-4049",

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T1 - Gecko-inspired chitosan adhesive for tissue repair

AU - Frost, Samuel J.

AU - Mawad, Damia

AU - Higgins, Michael J.

AU - Ruprai, Herleen

AU - Kuchel, Rhiannon

AU - Tilley, Richard D.

AU - Myers, Simon

AU - Hook, James M.

AU - Lauto, Antonio

PY - 2016

Y1 - 2016

N2 - The advent of nanotechnology has opened the possibility of fabricating nanoscopic pillars on the surface of polymeric films mimicking the Gecko’s foot, in an attempt to increase their adhesive capabilities enhanced by van der Waals forces. However, these forces are considerably weakened in a wet physiological environment. To circumvent this loss in force, currentbiocompatible adhesives with nanopillars require complex multiple-step fabrication, including an extra layer of adhesive coating to stabilize tissue bonding under physiological conditions. In this report, we describe a simple one-step fabrication process of a single-layer chitosan film that has pillars with base diameter in the range of 100–600 nm and a height of ̴70 nm. The nanostructured adhesive is laser-bonded to tissue and does not require pillar coating to enhance bonding in water. In comparison with a 'flat' adhesive (without pillars), the nanostructured adhesive bonded significantly stronger to tissue under either stress or pressure. Atomic force spectroscopy also confirmed the superior bonding capability of the nanostructured adhesive. This study demonstrates a one-step fabrication technique to produce a monolayer gecko-inspired adhesive that is biocompatible and bonds effectively to tissue.

AB - The advent of nanotechnology has opened the possibility of fabricating nanoscopic pillars on the surface of polymeric films mimicking the Gecko’s foot, in an attempt to increase their adhesive capabilities enhanced by van der Waals forces. However, these forces are considerably weakened in a wet physiological environment. To circumvent this loss in force, currentbiocompatible adhesives with nanopillars require complex multiple-step fabrication, including an extra layer of adhesive coating to stabilize tissue bonding under physiological conditions. In this report, we describe a simple one-step fabrication process of a single-layer chitosan film that has pillars with base diameter in the range of 100–600 nm and a height of ̴70 nm. The nanostructured adhesive is laser-bonded to tissue and does not require pillar coating to enhance bonding in water. In comparison with a 'flat' adhesive (without pillars), the nanostructured adhesive bonded significantly stronger to tissue under either stress or pressure. Atomic force spectroscopy also confirmed the superior bonding capability of the nanostructured adhesive. This study demonstrates a one-step fabrication technique to produce a monolayer gecko-inspired adhesive that is biocompatible and bonds effectively to tissue.

KW - nanotechnology

KW - chitosan

KW - adhesives

UR - http://hdl.handle.net/1959.7/uws:35917

U2 - 10.1038/am.2016.73

DO - 10.1038/am.2016.73

M3 - Article

SN - 1884-4049

VL - 8

JO - NPG Asia Materials

JF - NPG Asia Materials

M1 - e280

ER -

Gecko-inspired chitosan adhesive for tissue repair

Abstract

Open Access - Access Right Statement

Keywords

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