Generation of human islet progenitor cells via epithelial-to-mesenchymal transition

Wilson Wong; Anandwardhan A. Hardikar; Mugdha V. Joglekar

doi:10.1007/978-3-319-45307-1_9

Generation of human islet progenitor cells via epithelial-to-mesenchymal transition

Wilson Wong, Anandwardhan A. Hardikar, Mugdha V. Joglekar

Research output: Chapter in Book / Conference Paper › Chapter

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Abstract

Epithelial to mesenchymal transition (EMT) has been shown to occur during generation of human islet-derived progenitor cells (hIPCs), which have been demonstrated to retain potential to differentiate into insulin-producing cells. EMT is a biological process where epithelial cells go through a phenotypic change to become more mesenchymal-like. EMT is reported to form the basis of three distinct physiological and pathological processes: embryo formation/implantation, tissue repair and carcinoma/metastasis. We demonstrated that human islets undergo EMT when exposed to growth-promoting conditions in vitro. Here, we provide an overview of EMT, generation of hIPCs and other stem cells with this phenomenon, the debate surrounding the origin of lineage-committed progenitor cells and finally the role of microRNAs in regulating EMT in hIPCs.

Original language	English
Title of host publication	Pancreatic Islet Biology
Editors	Anandwardhan A. Hardikar
Place of Publication	Switzerland
Publisher	Springer
Pages	217-240
Number of pages	24
ISBN (Electronic)	9783319453071
ISBN (Print)	9783319453057
DOIs	https://doi.org/10.1007/978-3-319-45307-1_9
Publication status	Published - 2016

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title = "Generation of human islet progenitor cells via epithelial-to-mesenchymal transition",

abstract = "Epithelial to mesenchymal transition (EMT) has been shown to occur during generation of human islet-derived progenitor cells (hIPCs), which have been demonstrated to retain potential to differentiate into insulin-producing cells. EMT is a biological process where epithelial cells go through a phenotypic change to become more mesenchymal-like. EMT is reported to form the basis of three distinct physiological and pathological processes: embryo formation/implantation, tissue repair and carcinoma/metastasis. We demonstrated that human islets undergo EMT when exposed to growth-promoting conditions in vitro. Here, we provide an overview of EMT, generation of hIPCs and other stem cells with this phenomenon, the debate surrounding the origin of lineage-committed progenitor cells and finally the role of microRNAs in regulating EMT in hIPCs.",

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AU - Wong, Wilson

AU - Hardikar, Anandwardhan A.

AU - Joglekar, Mugdha V.

PY - 2016

Y1 - 2016

N2 - Epithelial to mesenchymal transition (EMT) has been shown to occur during generation of human islet-derived progenitor cells (hIPCs), which have been demonstrated to retain potential to differentiate into insulin-producing cells. EMT is a biological process where epithelial cells go through a phenotypic change to become more mesenchymal-like. EMT is reported to form the basis of three distinct physiological and pathological processes: embryo formation/implantation, tissue repair and carcinoma/metastasis. We demonstrated that human islets undergo EMT when exposed to growth-promoting conditions in vitro. Here, we provide an overview of EMT, generation of hIPCs and other stem cells with this phenomenon, the debate surrounding the origin of lineage-committed progenitor cells and finally the role of microRNAs in regulating EMT in hIPCs.

AB - Epithelial to mesenchymal transition (EMT) has been shown to occur during generation of human islet-derived progenitor cells (hIPCs), which have been demonstrated to retain potential to differentiate into insulin-producing cells. EMT is a biological process where epithelial cells go through a phenotypic change to become more mesenchymal-like. EMT is reported to form the basis of three distinct physiological and pathological processes: embryo formation/implantation, tissue repair and carcinoma/metastasis. We demonstrated that human islets undergo EMT when exposed to growth-promoting conditions in vitro. Here, we provide an overview of EMT, generation of hIPCs and other stem cells with this phenomenon, the debate surrounding the origin of lineage-committed progenitor cells and finally the role of microRNAs in regulating EMT in hIPCs.

UR - https://hdl.handle.net/1959.7/uws:59266

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DO - 10.1007/978-3-319-45307-1_9

M3 - Chapter

SN - 9783319453057

SP - 217

EP - 240

BT - Pancreatic Islet Biology

A2 - Hardikar, Anandwardhan A.

PB - Springer

CY - Switzerland

ER -

Generation of human islet progenitor cells via epithelial-to-mesenchymal transition

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