TY - JOUR
T1 - Genetic and environmental factors in vascular dementia : an update of blood brain barrier dysfunction
AU - Srinivasan, Vivek
AU - Braidy, Nady
AU - Chan, Eunice K. W.
AU - Xu, Ying-Hua
AU - Chan, Daniel K. Y.
PY - 2016
Y1 - 2016
N2 - Vascular dementia (VaD) describes a combination of both cognitive and behavioural manifestations associated with variable brain lesions of vascular origin. While vascular risk factors have been implicated in VaD, the relationship is most evident when the factors are considered together and not individually. This review will examine the significance of the integrity of blood brain barrier (BBB) tight junction (TJ) proteins - occludin and claudins in the pathophysiology of VaD. Specifically, some of the genetic contributors to VaD, namely those responsible for the integrity of the BBB, will be reviewed in detail. Moreover, environmental factors will be considered in conjunction with these genes to examine how the interaction of environmental and genetic factors contributes to one's susceptibility to VaD. © 2016 John Wiley and Sons Australia, Ltd.
AB - Vascular dementia (VaD) describes a combination of both cognitive and behavioural manifestations associated with variable brain lesions of vascular origin. While vascular risk factors have been implicated in VaD, the relationship is most evident when the factors are considered together and not individually. This review will examine the significance of the integrity of blood brain barrier (BBB) tight junction (TJ) proteins - occludin and claudins in the pathophysiology of VaD. Specifically, some of the genetic contributors to VaD, namely those responsible for the integrity of the BBB, will be reviewed in detail. Moreover, environmental factors will be considered in conjunction with these genes to examine how the interaction of environmental and genetic factors contributes to one's susceptibility to VaD. © 2016 John Wiley and Sons Australia, Ltd.
UR - https://hdl.handle.net/1959.7/uws:64170
U2 - 10.1111/1440-1681.12558
DO - 10.1111/1440-1681.12558
M3 - Article
SN - 0305-1870
VL - 43
SP - 515
EP - 521
JO - Clinical and Experimental Pharmacology and Physiology
JF - Clinical and Experimental Pharmacology and Physiology
IS - 5
ER -