Genomic and molecular analyses identify molecular subtypes of pancreatic cancer recurrence

Stephan B. Dreyer; Rosie Upstill-Goddard; Assya Legrini; Andrew V. Biankin; Nigel B. Jamieson; David K. Chang; Sarah Allison; Dario Beraldi; Euan Cameron; Susanna L. Cooke; Richard Cunningham; Paul Grimwood; Shane Kelly; John Marshall; Brian McDade; Elizabeth A. Musgrove; Donna Ramsay; Lisa Evers; Selma Rebus; Lola Rahib; Bryan Serrels; Colin J. McKay; Paul Westwood; Nicola Williams; Fraser Duthie; William Shen; Antonio [Unknown]; Amber L. Johns; Anthony J. Gill; Lorraine A. Chantrill; Paul Timpson; Angela Chou; Marina Pajic; Tanya Dwarte; David Herrmann; Claire Vennin; Thomas R. Cox; Brooke Pereira; Shona Ritchiee; Daniel A. Reed; Cecilia R. Chambers; Xanthe Metcalf; Max Nobis; Gloria Jeong; Lara Kenyon; Ruth J. Lyons; Nicola Waddell; John V. Pearson; Ann-Marie Patch; Katia Nones; Neil D. Merrett; Neil D. et al.; et al.

doi:10.1053/j.gastro.2021.09.022

Genomic and molecular analyses identify molecular subtypes of pancreatic cancer recurrence

Stephan B. Dreyer
, Rosie Upstill-Goddard
, Assya Legrini
, Andrew V. Biankin
, Nigel B. Jamieson
, David K. Chang
, Sarah Allison
, Dario Beraldi
, Euan Cameron
, Susanna L. Cooke
, Richard Cunningham
, Paul Grimwood
, Shane Kelly
, John Marshall
, Brian McDade
, Elizabeth A. Musgrove
, Donna Ramsay
, Lisa Evers
, Selma Rebus
, Lola Rahib

Bryan Serrels, Colin J. McKay, Paul Westwood, Nicola Williams, Fraser Duthie, William Shen, Antonio [Unknown], Amber L. Johns, Anthony J. Gill, Lorraine A. Chantrill, Paul Timpson, Angela Chou, Marina Pajic, Tanya Dwarte, David Herrmann, Claire Vennin, Thomas R. Cox, Brooke Pereira, Shona Ritchiee, Daniel A. Reed, Cecilia R. Chambers, Xanthe Metcalf, Max Nobis, Gloria Jeong, Lara Kenyon, Ruth J. Lyons, Nicola Waddell, John V. Pearson, Ann-Marie Patch, Katia Nones, Neil D. Merrett, Neil D. et al., et al.

Research output: Contribution to journal › Article › peer-review

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Abstract

Pancreatic cancer (PC) remains a highly lethal malignancy, and most patients with localized disease that undergo surgical resection still succumb to recurrent disease. Pattern of recurrence after pancreatectomy is heterogenous, with some studies illustrating that site of recurrence can be associated with prognosis.1 Another study suggested that tumors that develop local and distant recurrence can be regarded as a homogenous disease with similar outcomes.2 Here we investigate novel molecular determinants of recurrence pattern after pancreatectomy for PC.

Original language	English
Pages (from-to)	320-324.e4
Number of pages	9
Journal	Gastroenterology
Volume	162
Issue number	1
DOIs	https://doi.org/10.1053/j.gastro.2021.09.022
Publication status	Published - Jan 2022

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SDG 3 Good Health and Well-being

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10.1053/j.gastro.2021.09.022

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Dreyer, S. B., Upstill-Goddard, R., Legrini, A., Biankin, A. V., Jamieson, N. B., Chang, D. K., Allison, S., Beraldi, D., Cameron, E., Cooke, S. L., Cunningham, R., Grimwood, P., Kelly, S., Marshall, J., McDade, B., Musgrove, E. A., Ramsay, D., Evers, L., Rebus, S., ... et al. (2022). Genomic and molecular analyses identify molecular subtypes of pancreatic cancer recurrence. Gastroenterology, 162(1), 320-324.e4. https://doi.org/10.1053/j.gastro.2021.09.022

@article{ad3ddc705eec42b0a5c9433ae9742692,

title = "Genomic and molecular analyses identify molecular subtypes of pancreatic cancer recurrence",

abstract = "Pancreatic cancer (PC) remains a highly lethal malignancy, and most patients with localized disease that undergo surgical resection still succumb to recurrent disease. Pattern of recurrence after pancreatectomy is heterogenous, with some studies illustrating that site of recurrence can be associated with prognosis.1 Another study suggested that tumors that develop local and distant recurrence can be regarded as a homogenous disease with similar outcomes.2 Here we investigate novel molecular determinants of recurrence pattern after pancreatectomy for PC.",

author = "Dreyer, \{Stephan B.\} and Rosie Upstill-Goddard and Assya Legrini and Biankin, \{Andrew V.\} and Jamieson, \{Nigel B.\} and Chang, \{David K.\} and Sarah Allison and Dario Beraldi and Euan Cameron and Cooke, \{Susanna L.\} and Richard Cunningham and Paul Grimwood and Shane Kelly and John Marshall and Brian McDade and Musgrove, \{Elizabeth A.\} and Donna Ramsay and Lisa Evers and Selma Rebus and Lola Rahib and Bryan Serrels and McKay, \{Colin J.\} and Paul Westwood and Nicola Williams and Fraser Duthie and William Shen and Antonio [Unknown] and Johns, \{Amber L.\} and Gill, \{Anthony J.\} and Chantrill, \{Lorraine A.\} and Paul Timpson and Angela Chou and Marina Pajic and Tanya Dwarte and David Herrmann and Claire Vennin and Cox, \{Thomas R.\} and Brooke Pereira and Shona Ritchiee and Reed, \{Daniel A.\} and Chambers, \{Cecilia R.\} and Xanthe Metcalf and Max Nobis and Gloria Jeong and Lara Kenyon and Lyons, \{Ruth J.\} and Nicola Waddell and Pearson, \{John V.\} and Ann-Marie Patch and Katia Nones and Merrett, \{Neil D.\} and \{et al.\}, \{Neil D.\} and \{et al.\}",

year = "2022",

month = jan,

doi = "10.1053/j.gastro.2021.09.022",

language = "English",

volume = "162",

pages = "320--324.e4",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders",

number = "1",

}

Dreyer, SB, Upstill-Goddard, R, Legrini, A, Biankin, AV, Jamieson, NB, Chang, DK, Allison, S, Beraldi, D, Cameron, E, Cooke, SL, Cunningham, R, Grimwood, P, Kelly, S, Marshall, J, McDade, B, Musgrove, EA, Ramsay, D, Evers, L, Rebus, S, Rahib, L, Serrels, B, McKay, CJ, Westwood, P, Williams, N, Duthie, F, Shen, W, [Unknown], A, Johns, AL, Gill, AJ, Chantrill, LA, Timpson, P, Chou, A, Pajic, M, Dwarte, T, Herrmann, D, Vennin, C, Cox, TR, Pereira, B, Ritchiee, S, Reed, DA, Chambers, CR, Metcalf, X, Nobis, M, Jeong, G, Kenyon, L, Lyons, RJ, Waddell, N, Pearson, JV, Patch, A-M, Nones, K, Merrett, ND, et al., ND & et al. 2022, 'Genomic and molecular analyses identify molecular subtypes of pancreatic cancer recurrence', Gastroenterology, vol. 162, no. 1, pp. 320-324.e4. https://doi.org/10.1053/j.gastro.2021.09.022

TY - JOUR

T1 - Genomic and molecular analyses identify molecular subtypes of pancreatic cancer recurrence

AU - Dreyer, Stephan B.

AU - Upstill-Goddard, Rosie

AU - Legrini, Assya

AU - Biankin, Andrew V.

AU - Jamieson, Nigel B.

AU - Chang, David K.

AU - Allison, Sarah

AU - Beraldi, Dario

AU - Cameron, Euan

AU - Cooke, Susanna L.

AU - Cunningham, Richard

AU - Grimwood, Paul

AU - Kelly, Shane

AU - Marshall, John

AU - McDade, Brian

AU - Musgrove, Elizabeth A.

AU - Ramsay, Donna

AU - Evers, Lisa

AU - Rebus, Selma

AU - Rahib, Lola

AU - Serrels, Bryan

AU - McKay, Colin J.

AU - Westwood, Paul

AU - Williams, Nicola

AU - Duthie, Fraser

AU - Shen, William

AU - [Unknown], Antonio

AU - Johns, Amber L.

AU - Gill, Anthony J.

AU - Chantrill, Lorraine A.

AU - Timpson, Paul

AU - Chou, Angela

AU - Pajic, Marina

AU - Dwarte, Tanya

AU - Herrmann, David

AU - Vennin, Claire

AU - Cox, Thomas R.

AU - Pereira, Brooke

AU - Ritchiee, Shona

AU - Reed, Daniel A.

AU - Chambers, Cecilia R.

AU - Metcalf, Xanthe

AU - Nobis, Max

AU - Jeong, Gloria

AU - Kenyon, Lara

AU - Lyons, Ruth J.

AU - Waddell, Nicola

AU - Pearson, John V.

AU - Patch, Ann-Marie

AU - Nones, Katia

AU - Merrett, Neil D.

AU - et al., Neil D.

AU - et al., null

PY - 2022/1

Y1 - 2022/1

N2 - Pancreatic cancer (PC) remains a highly lethal malignancy, and most patients with localized disease that undergo surgical resection still succumb to recurrent disease. Pattern of recurrence after pancreatectomy is heterogenous, with some studies illustrating that site of recurrence can be associated with prognosis.1 Another study suggested that tumors that develop local and distant recurrence can be regarded as a homogenous disease with similar outcomes.2 Here we investigate novel molecular determinants of recurrence pattern after pancreatectomy for PC.

AB - Pancreatic cancer (PC) remains a highly lethal malignancy, and most patients with localized disease that undergo surgical resection still succumb to recurrent disease. Pattern of recurrence after pancreatectomy is heterogenous, with some studies illustrating that site of recurrence can be associated with prognosis.1 Another study suggested that tumors that develop local and distant recurrence can be regarded as a homogenous disease with similar outcomes.2 Here we investigate novel molecular determinants of recurrence pattern after pancreatectomy for PC.

UR - http://hdl.handle.net/1959.7/uws:67029

U2 - 10.1053/j.gastro.2021.09.022

DO - 10.1053/j.gastro.2021.09.022

M3 - Article

C2 - 34534536

SN - 0016-5085

VL - 162

SP - 320-324.e4

JO - Gastroenterology

JF - Gastroenterology

IS - 1

ER -

Genomic and molecular analyses identify molecular subtypes of pancreatic cancer recurrence

Abstract

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