TY - JOUR
T1 - Genomic footprints of activated telomere maintenance mechanisms in cancer
AU - Sieverling, Lina
AU - Hong, Chen
AU - Koser, Sandra D.
AU - Ginsbach, Philip
AU - Kleinheinz, Kortine
AU - Hutter, Barbara
AU - Braun, Delia M.
AU - Cortés-Ciriano, Isidro
AU - Xi, Ruibin
AU - Kabbe, Rolf
AU - Park, Peter J.
AU - Eils, Roland
AU - Schlesner, Matthias
AU - PCAWG-Structural Variation Working Group,
AU - Brors, Benedikt
AU - Rippe, Karsten
AU - Jones, David T.W.
AU - Feuerbach, Lars
AU - PCAWG Consortium,
AU - Merrett, Neil D.
AU - et al.,
PY - 2020/2/5
Y1 - 2020/2/5
N2 - Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types aggregated within the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium to characterize the genomic footprints of these mechanisms. While the telomere content of tumors with ATRX or DAXX mutations (ATRX/DAXX(trunc)) is increased, tumors with TERT modifications show a moderate decrease of telomere content. One quarter of all tumor samples contain somatic integrations of telomeric sequences into non-telomeric DNA. This fraction is increased to 80% prevalence in ATRX/DAXX(trunc) tumors, which carry an aberrant telomere variant repeat (TVR) distribution as another genomic marker. The latter feature includes enrichment or depletion of the previously undescribed singleton TVRs TTCGGG and TTTGGG, respectively. Our systematic analysis provides new insight into the recurrent genomic alterations associated with telomere maintenance mechanisms in cancer. There are amendments to this Article, which can be found at - https://doi.org/10.1038/s41467-022-32328-7
AB - Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types aggregated within the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium to characterize the genomic footprints of these mechanisms. While the telomere content of tumors with ATRX or DAXX mutations (ATRX/DAXX(trunc)) is increased, tumors with TERT modifications show a moderate decrease of telomere content. One quarter of all tumor samples contain somatic integrations of telomeric sequences into non-telomeric DNA. This fraction is increased to 80% prevalence in ATRX/DAXX(trunc) tumors, which carry an aberrant telomere variant repeat (TVR) distribution as another genomic marker. The latter feature includes enrichment or depletion of the previously undescribed singleton TVRs TTCGGG and TTTGGG, respectively. Our systematic analysis provides new insight into the recurrent genomic alterations associated with telomere maintenance mechanisms in cancer. There are amendments to this Article, which can be found at - https://doi.org/10.1038/s41467-022-32328-7
U2 - 10.1038/s41467-019-13824-9
DO - 10.1038/s41467-019-13824-9
M3 - Article
SN - 2041-1723
VL - 11
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 733
ER -
