Global mortality from dementia : application of a new method and results from the Global Burden of Disease study 2019

E. Nichols; F. Abd-Allah; A. Abdoli; A. E. Abosetugn; W. A. Abrha; A. Abualhasan; E. Abu-Gharbieh; R. O. Akinyemi; F. Alahdab; F. M. Alanezi; V. Alipour; I. Ansari; J. Arabloo; A. Ashraf-Ganjouei; A. Avan; G. Ayano; Z. -U. -D. Babar; A. A. Baig; M. Banach; M. A. Barboza; S. L. Barker-Collo; B.T. Baune; A. S. Bhagavathula; K. Bhattacharyya; A. Bijani; A. Biondi; T. A. Birhan; A. Biswas; S. R. Bolla; A. Boloor; C. Brayne; H. Brenner; K. Burkart; R. A. Burns; S. B. Nagaraja; F. Carvalho; L. F. S. Castro-De-araujo; F. Catalá-López; E. Cerin; A. Cernigliaro; N. Cherbuin; J. -Y. J. Choi; D. -T. Chu; B. Dagnew; X. Dai; L. Dandona; R. Dandona; D. Diaz; Z. S. D. Forooshani; Felix Akpojene Ogbo; null et al.

doi:10.1002/trc2.12200

Global mortality from dementia : application of a new method and results from the Global Burden of Disease study 2019

E. Nichols, F. Abd-Allah, A. Abdoli, A. E. Abosetugn, W. A. Abrha, A. Abualhasan, E. Abu-Gharbieh, R. O. Akinyemi, F. Alahdab, F. M. Alanezi, V. Alipour, I. Ansari, J. Arabloo, A. Ashraf-Ganjouei, A. Avan, G. Ayano, Z. -U. -D. Babar, A. A. Baig, M. Banach, M. A. BarbozaS. L. Barker-Collo, B.T. Baune, A. S. Bhagavathula, K. Bhattacharyya, A. Bijani, A. Biondi, T. A. Birhan, A. Biswas, S. R. Bolla, A. Boloor, C. Brayne, H. Brenner, K. Burkart, R. A. Burns, S. B. Nagaraja, F. Carvalho, L. F. S. Castro-De-araujo, F. Catalá-López, E. Cerin, A. Cernigliaro, N. Cherbuin, J. -Y. J. Choi, D. -T. Chu, B. Dagnew, X. Dai, L. Dandona, R. Dandona, D. Diaz, Z. S. D. Forooshani, Felix Akpojene Ogbo, et al.

Western Sydney University

Research output: Contribution to journal › Article › peer-review

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Abstract

Introduction: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods: We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. Results: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27-2.71]) than men (0.56 million [0.14-1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-tomale ratio 1.19 [1.10-1.26]). Due to population aging, there was a large increase in allage mortality rates from dementia between 1990 and 2019 (100.1% [89.1-117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally.

Original language	English
Article number	e12200
Number of pages	28
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	7
Issue number	1
DOIs	https://doi.org/10.1002/trc2.12200
Publication status	Published - 2021

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© 2021 The Authors.

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This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Nichols, E., Abd-Allah, F., Abdoli, A., Abosetugn, A. E., Abrha, W. A., Abualhasan, A., Abu-Gharbieh, E., Akinyemi, R. O., Alahdab, F., Alanezi, F. M., Alipour, V., Ansari, I., Arabloo, J., Ashraf-Ganjouei, A., Avan, A., Ayano, G., Babar, Z. .-U. .-D., Baig, A. A., Banach, M., ... et al. (2021). Global mortality from dementia : application of a new method and results from the Global Burden of Disease study 2019. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 7(1), Article e12200. https://doi.org/10.1002/trc2.12200

@article{57be610b541f49c580f88119335b8ba8,

title = "Global mortality from dementia : application of a new method and results from the Global Burden of Disease study 2019",

abstract = "Introduction: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods: We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. Results: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27-2.71]) than men (0.56 million [0.14-1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-tomale ratio 1.19 [1.10-1.26]). Due to population aging, there was a large increase in allage mortality rates from dementia between 1990 and 2019 (100.1% [89.1-117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally.",

author = "E. Nichols and F. Abd-Allah and A. Abdoli and Abosetugn, {A. E.} and Abrha, {W. A.} and A. Abualhasan and E. Abu-Gharbieh and Akinyemi, {R. O.} and F. Alahdab and Alanezi, {F. M.} and V. Alipour and I. Ansari and J. Arabloo and A. Ashraf-Ganjouei and A. Avan and G. Ayano and Babar, {Z. -U. -D.} and Baig, {A. A.} and M. Banach and Barboza, {M. A.} and Barker-Collo, {S. L.} and B.T. Baune and Bhagavathula, {A. S.} and K. Bhattacharyya and A. Bijani and A. Biondi and Birhan, {T. A.} and A. Biswas and Bolla, {S. R.} and A. Boloor and C. Brayne and H. Brenner and K. Burkart and Burns, {R. A.} and Nagaraja, {S. B.} and F. Carvalho and Castro-De-araujo, {L. F. S.} and F. Catal{\'a}-L{\'o}pez and E. Cerin and A. Cernigliaro and N. Cherbuin and Choi, {J. -Y. J.} and Chu, {D. -T.} and B. Dagnew and X. Dai and L. Dandona and R. Dandona and D. Diaz and Forooshani, {Z. S. D.} and Ogbo, {Felix Akpojene} and {et al.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors.",

year = "2021",

doi = "10.1002/trc2.12200",

language = "English",

volume = "7",

journal = "Alzheimer's and Dementia: Translational Research and Clinical Interventions",

issn = "2352-8737",

publisher = "John Wiley & Sons",

number = "1",

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Nichols, E, Abd-Allah, F, Abdoli, A, Abosetugn, AE, Abrha, WA, Abualhasan, A, Abu-Gharbieh, E, Akinyemi, RO, Alahdab, F, Alanezi, FM, Alipour, V, Ansari, I, Arabloo, J, Ashraf-Ganjouei, A, Avan, A, Ayano, G, Babar, Z-U-D, Baig, AA, Banach, M, Barboza, MA, Barker-Collo, SL, Baune, BT, Bhagavathula, AS, Bhattacharyya, K, Bijani, A, Biondi, A, Birhan, TA, Biswas, A, Bolla, SR, Boloor, A, Brayne, C, Brenner, H, Burkart, K, Burns, RA, Nagaraja, SB, Carvalho, F, Castro-De-araujo, LFS, Catalá-López, F, Cerin, E, Cernigliaro, A, Cherbuin, N, Choi, J-YJ, Chu, D-T, Dagnew, B, Dai, X, Dandona, L, Dandona, R, Diaz, D, Forooshani, ZSD, Ogbo, FA & et al. 2021, 'Global mortality from dementia : application of a new method and results from the Global Burden of Disease study 2019', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 7, no. 1, e12200. https://doi.org/10.1002/trc2.12200

TY - JOUR

T1 - Global mortality from dementia : application of a new method and results from the Global Burden of Disease study 2019

AU - Nichols, E.

AU - Abd-Allah, F.

AU - Abdoli, A.

AU - Abosetugn, A. E.

AU - Abrha, W. A.

AU - Abualhasan, A.

AU - Abu-Gharbieh, E.

AU - Akinyemi, R. O.

AU - Alahdab, F.

AU - Alanezi, F. M.

AU - Alipour, V.

AU - Ansari, I.

AU - Arabloo, J.

AU - Ashraf-Ganjouei, A.

AU - Avan, A.

AU - Ayano, G.

AU - Babar, Z. -U. -D.

AU - Baig, A. A.

AU - Banach, M.

AU - Barboza, M. A.

AU - Barker-Collo, S. L.

AU - Baune, B.T.

AU - Bhagavathula, A. S.

AU - Bhattacharyya, K.

AU - Bijani, A.

AU - Biondi, A.

AU - Birhan, T. A.

AU - Biswas, A.

AU - Bolla, S. R.

AU - Boloor, A.

AU - Brayne, C.

AU - Brenner, H.

AU - Burkart, K.

AU - Burns, R. A.

AU - Nagaraja, S. B.

AU - Carvalho, F.

AU - Castro-De-araujo, L. F. S.

AU - Catalá-López, F.

AU - Cerin, E.

AU - Cernigliaro, A.

AU - Cherbuin, N.

AU - Choi, J. -Y. J.

AU - Chu, D. -T.

AU - Dagnew, B.

AU - Dai, X.

AU - Dandona, L.

AU - Dandona, R.

AU - Diaz, D.

AU - Forooshani, Z. S. D.

AU - Ogbo, Felix Akpojene

AU - et al., null

PY - 2021

Y1 - 2021

N2 - Introduction: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods: We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. Results: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27-2.71]) than men (0.56 million [0.14-1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-tomale ratio 1.19 [1.10-1.26]). Due to population aging, there was a large increase in allage mortality rates from dementia between 1990 and 2019 (100.1% [89.1-117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally.

AB - Introduction: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods: We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. Results: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27-2.71]) than men (0.56 million [0.14-1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-tomale ratio 1.19 [1.10-1.26]). Due to population aging, there was a large increase in allage mortality rates from dementia between 1990 and 2019 (100.1% [89.1-117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally.

UR - https://hdl.handle.net/1959.7/uws:76931

U2 - 10.1002/trc2.12200

DO - 10.1002/trc2.12200

M3 - Article

SN - 2352-8737

VL - 7

JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions

JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions

IS - 1

M1 - e12200

ER -

Global mortality from dementia : application of a new method and results from the Global Burden of Disease study 2019

Abstract

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