TY - JOUR
T1 - Global, regional, and national burden of epilepsy, 1990 - 2016 : a systematic analysis for the Global Burden of Disease Study 2016
AU - Beghi, Ettore
AU - Giussani, Giorgia
AU - Nichols, Emma
AU - Abd-Allah, Foad
AU - Abdela, Jemal
AU - Abdelalim, Ahmed
AU - Abraha, Haftom Niguse
AU - Adib, Mina G.
AU - Agrawal, Sutapa
AU - Alahdab, Fares
AU - Awasthi, Ashish
AU - Ayele, Yohanes
AU - Barboza, Miguel A.
AU - Belachew, Abate Bekele
AU - Biadgo, Belete
AU - Bijani, Ali
AU - Bitew, Helen
AU - Carvalho, Félix
AU - Chaiah, Yazan
AU - Daryani, Ahmad
AU - Do, Huyen Phuc
AU - Dubey, Manisha
AU - Endries, Aman Yesuf Yesuf
AU - Eskandarieh, Sharareh
AU - Faro, Andre
AU - Farzadfar, Farshad
AU - Fereshtehnejad, Seyed-Mohammad
AU - Fernandes, Eduarda
AU - Fijabi, Daniel Obadare
AU - Filip, Irina
AU - Fischer, Florian
AU - Gebre, Abadi Kahsu
AU - Tsadik, Afewerki Gebremeskel
AU - Gebremichael, Teklu Gebrehiwo
AU - Gezae, Kebede Embaye
AU - Ghasemi-Kasman, Maryam
AU - Weldegwergs, Kidu Gidey
AU - Degefa, Meaza Girma
AU - Gnedovskaya, Elena V.
AU - Hagos, Tekleberhan B.
AU - Haj-Mirzaian, Arvin
AU - Haj-Mirzaian, Arya
AU - Hassen, Hamid Yimam
AU - Hay, Simon I.
AU - Jakovljevic, Mihajlo
AU - Kasaeian, Amir
AU - Kassa, Tesfaye Dessale
AU - Khader, Yousef Saleh
AU - Khalil, Ibrahim
AU - Khan, Ejaz Ahmad
AU - Khubchandani, Jagdish
AU - Kisa, Adnan
AU - Krohn, Kristopher J.
AU - Kulkarni, Chanda
AU - Nirayo, Yirga Legesse
AU - Mackay, Mark T.
AU - Majdan, Marek
AU - Majeed, Azeem
AU - Manhertz, Treh
AU - Mehndiratta, Man Mohan
AU - Mekonen, Tesfa
AU - Meles, Hagazi Gebre
AU - Mengistu, Getnet
AU - Mohammed, Shafiu
AU - Naghavi, Mohsen
AU - Mokdad, Ali H.
AU - Mustafa, Ghulam
AU - Irvani, Seyed Sina Naghibi
AU - Nguyen, Long Hoang
AU - Nixon, Molly R.
AU - Ogbo, Felix Akpojene
PY - 2019
Y1 - 2019
N2 - Background: Seizures and their consequences contribute to the burden of epilepsy because they can cause health loss (premature mortality and residual disability). Data on the burden of epilepsy are needed for health-care planning and resource allocation. The aim of this study was to quantify health loss due to epilepsy by age, sex, year, and location using data from the Global Burden of Diseases, Injuries, and Risk Factors Study. Methods: We assessed the burden of epilepsy in 195 countries and territories from 1990 to 2016. Burden was measured as deaths, prevalence, and disability-adjusted life-years (DALYs; a summary measure of health loss defined by the sum of years of life lost [YLLs] for premature mortality and years lived with disability), by age, sex, year, location, and Socio-demographic Index (SDI; a compound measure of income per capita, education, and fertility). Vital registrations and verbal autopsies provided information about deaths, and data on the prevalence and severity of epilepsy largely came from population representative surveys. All estimates were calculated with 95% uncertainty intervals (UIs). Interpretation: Despite the decrease in the disease burden from 1990 to 2016, epilepsy is still an important cause of disability and mortality. Standardised collection of data on epilepsy in population representative surveys will strengthen the estimates, particularly in countries for which we currently have no or sparse data and if additional data is collected on severity, causes, and treatment. Sizeable gains in reducing the burden of epilepsy might be expected from improved access to existing treatments in low-income countries and from the development of new effective drugs worldwide.
AB - Background: Seizures and their consequences contribute to the burden of epilepsy because they can cause health loss (premature mortality and residual disability). Data on the burden of epilepsy are needed for health-care planning and resource allocation. The aim of this study was to quantify health loss due to epilepsy by age, sex, year, and location using data from the Global Burden of Diseases, Injuries, and Risk Factors Study. Methods: We assessed the burden of epilepsy in 195 countries and territories from 1990 to 2016. Burden was measured as deaths, prevalence, and disability-adjusted life-years (DALYs; a summary measure of health loss defined by the sum of years of life lost [YLLs] for premature mortality and years lived with disability), by age, sex, year, location, and Socio-demographic Index (SDI; a compound measure of income per capita, education, and fertility). Vital registrations and verbal autopsies provided information about deaths, and data on the prevalence and severity of epilepsy largely came from population representative surveys. All estimates were calculated with 95% uncertainty intervals (UIs). Interpretation: Despite the decrease in the disease burden from 1990 to 2016, epilepsy is still an important cause of disability and mortality. Standardised collection of data on epilepsy in population representative surveys will strengthen the estimates, particularly in countries for which we currently have no or sparse data and if additional data is collected on severity, causes, and treatment. Sizeable gains in reducing the burden of epilepsy might be expected from improved access to existing treatments in low-income countries and from the development of new effective drugs worldwide.
KW - World health
KW - epilepsy
KW - health surveys
UR - http://hdl.handle.net/1959.7/uws:51623
U2 - 10.1016/S1474-4422(18)30454-X
DO - 10.1016/S1474-4422(18)30454-X
M3 - Article
SN - 1474-4422
VL - 18
SP - 357
EP - 375
JO - The Lancet Neurology
JF - The Lancet Neurology
IS - 4
ER -