TY - JOUR
T1 - Graphene-MoS2 polyfunctional hybrid hydrogels for the healing of transected Achilles tendon
AU - Esmaeili Fard Barzegar, Peyman
AU - Mohammadi, Zahra
AU - Sattari, Shabnam
AU - Beiranvand, Zahra
AU - Salahvarzi, Maryam
AU - Rossoli, Kiarash
AU - Adeli, Saeid
AU - Beyranvand, Siamak
AU - Maleki, Sara
AU - Kazeminava, Fahimeh
AU - Mousazadeh, Hanieh
AU - Raisi, Abbas
AU - Farjanikish, Ghasem
AU - Sadegh, Amin Bigham
AU - Shahbazi, Feizollah
AU - Adeli, Mohsen
PY - 2022
Y1 - 2022
N2 - Healing of injured tendon is a major clinical challenge in orthopaedic medicine, due to the poor regenerative potential of this tissue. Two-dimensional nanomaterials, as versatile scaffolds, have shown a great potential to support, trigger and accelerate the tendon regeneration. However, weak mechanical properties, poor functionality and low biocompatibility of these scaffolds as well as post-surgery infections are main drawbacks that limit their development in the higher clinical phases. In this work, a series of hydrogels consisting polyglycerol functionalized reduced graphene oxide (PG), polyglycerol-functionalized molybdenum disulfide (PMoS2) and PG/PMoS2 hybrid within the gelatin matrix are formulated in new scaffolds and their ability for the healing of injured Achilles tendon, due to their high mechanical properties, low toxicity, cell proliferation enhancement, and antibacterial activities is investigated. While scaffolds containing PG and PMoS2 showed a moderate tendon regeneration and anti-inflammatory effect, respectively, their hybridization into PG/PMoS2 demonstrated a synergistic healing efficiency. Along the same line, an accelerated return of tendon function with low peritendinous adhesion and low cross-sectional area in animal group treated with scaffold containing PG/PMoS2 was observed. Taking advantage of the high biocompatibility, high strength, straightforward construction and fast tendon regeneration, PG/PMoS2 can be used as a new scaffold for the future tissue engineering.
AB - Healing of injured tendon is a major clinical challenge in orthopaedic medicine, due to the poor regenerative potential of this tissue. Two-dimensional nanomaterials, as versatile scaffolds, have shown a great potential to support, trigger and accelerate the tendon regeneration. However, weak mechanical properties, poor functionality and low biocompatibility of these scaffolds as well as post-surgery infections are main drawbacks that limit their development in the higher clinical phases. In this work, a series of hydrogels consisting polyglycerol functionalized reduced graphene oxide (PG), polyglycerol-functionalized molybdenum disulfide (PMoS2) and PG/PMoS2 hybrid within the gelatin matrix are formulated in new scaffolds and their ability for the healing of injured Achilles tendon, due to their high mechanical properties, low toxicity, cell proliferation enhancement, and antibacterial activities is investigated. While scaffolds containing PG and PMoS2 showed a moderate tendon regeneration and anti-inflammatory effect, respectively, their hybridization into PG/PMoS2 demonstrated a synergistic healing efficiency. Along the same line, an accelerated return of tendon function with low peritendinous adhesion and low cross-sectional area in animal group treated with scaffold containing PG/PMoS2 was observed. Taking advantage of the high biocompatibility, high strength, straightforward construction and fast tendon regeneration, PG/PMoS2 can be used as a new scaffold for the future tissue engineering.
UR - https://hdl.handle.net/1959.7/uws:77278
U2 - 10.1016/j.bioadv.2022.212820
DO - 10.1016/j.bioadv.2022.212820
M3 - Article
SN - 2772-9516
VL - 137
JO - Biomaterials Advances
JF - Biomaterials Advances
M1 - 212820
ER -