Health-related quality of life of children and adolescents with cerebral palsy in low- and middle-income countries : a systematic review

Rosalie Power, Catherine King, Mohammad Muhit, Eamin Heanoy, Claire Galea, Cheryl Jones, Nadia Badawi, Gulam Khandaker

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

AIM To systematically review literature on health-related quality of life (HRQoL) of children and adolescents (≤18yo) with cerebral palsy (CP) from low- and middle-income countries (LMICs) to identify trends in HRQoL and areas for future research. METHOD We systematically reviewed six key bibliographic databases and two reviewers independently screened results. Peer-reviewed original articles examining HRQoL of children from LMICs were eligible. RESULTS A total of 22 524 papers were identified, of which 16, from eight LMICs, were included. Four measures of HRQoL were used; Child Health Questionnaire Parent Form 50 (n=5); Paediatric Quality of Life Inventory 3.0 and 4.0 (n=4); CP Quality of Life Questionnaire for Children (n=4); Lifestyle Assessment Questionnaire CP (n=3). Children with CP from LMICs (n=1579; 2–18y) had significantly poorer HRQoL on all instrument dimensions when compared to age-matched controls (p<0.003) and on all except two dimensions when compared to peers in high-income countries (p<0.001). Physical well-being dimensions of HRQoL were poorest overall and associated with impaired motor function. INTERPRETATION Research to improve HRQoL in LMICs is required and should address all aspects of HRQoL. Future research is recommended to incorporate multi-respondent assessment, utilize both general and CP-specific measures of HRQoL, and delineate adolescents as a unique cohort.
Original languageEnglish
Pages (from-to)469-479
Number of pages11
JournalDevelopmental Medicine and Child Neurology
Volume60
Issue number5
DOIs
Publication statusPublished - 2018

Keywords

  • cerebral palsy
  • health
  • quality of life
  • teenagers

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