Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer

Tingting Zheng; Zujun Que; Lijing Jiao; Yani Kang; Yabin Gong; Jialin Yao; Chao Ma; Ling Bi; Qihan Dong; Xiaodong Zhao; Ling Xu

doi:10.1038/s41598-017-05146-x

Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer

Tingting Zheng, Zujun Que, Lijing Jiao, Yani Kang, Yabin Gong, Jialin Yao, Chao Ma, Ling Bi, Qihan Dong, Xiaodong Zhao, Ling Xu

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

Lung cancer represents a major cause of cancer-related death worldwide. Although various tactics and anti-tumor drugs have been used to improve curative effects, five-year survival rate of lung cancer patients remains poor. In this study, we investigated the action and underlying mechanisms of our recently optimized Chinese herbal formula Yangyinjiedu (YYJD) against lung cancer. YYJD significantly inhibits the proliferation of lung cancer cell lines (95-D, A549, H460 and H1975) by inducing cell cycle arrest and senescence in a dose-dependent manner. In particular, YYJD induces significant G2/M phase arrest and inhibits the colony formation of lung cancer cells. Moreover, we found that administration of YYJD could inhibit the growth of xenografted lung cancer cells in nude mice without loss in body weight. Our findings suggest that the herbal formula YYJD is a potential anti-tumor agent against lung cancer.

Original language	English
Article number	4984
Number of pages	9
Journal	Scientific Reports
Volume	7
DOIs	https://doi.org/10.1038/s41598-017-05146-x
Publication status	Published - 2017

Open Access - Access Right Statement

Â© The Author(s) 2017 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Keywords

cancer
lungs
medicine_Chinese
mice

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41598-017-05146-x

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title = "Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer",

abstract = "Lung cancer represents a major cause of cancer-related death worldwide. Although various tactics and anti-tumor drugs have been used to improve curative effects, five-year survival rate of lung cancer patients remains poor. In this study, we investigated the action and underlying mechanisms of our recently optimized Chinese herbal formula Yangyinjiedu (YYJD) against lung cancer. YYJD significantly inhibits the proliferation of lung cancer cell lines (95-D, A549, H460 and H1975) by inducing cell cycle arrest and senescence in a dose-dependent manner. In particular, YYJD induces significant G2/M phase arrest and inhibits the colony formation of lung cancer cells. Moreover, we found that administration of YYJD could inhibit the growth of xenografted lung cancer cells in nude mice without loss in body weight. Our findings suggest that the herbal formula YYJD is a potential anti-tumor agent against lung cancer.",

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doi = "10.1038/s41598-017-05146-x",

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TY - JOUR

T1 - Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer

AU - Zheng, Tingting

AU - Que, Zujun

AU - Jiao, Lijing

AU - Kang, Yani

AU - Gong, Yabin

AU - Yao, Jialin

AU - Ma, Chao

AU - Bi, Ling

AU - Dong, Qihan

AU - Zhao, Xiaodong

AU - Xu, Ling

PY - 2017

Y1 - 2017

N2 - Lung cancer represents a major cause of cancer-related death worldwide. Although various tactics and anti-tumor drugs have been used to improve curative effects, five-year survival rate of lung cancer patients remains poor. In this study, we investigated the action and underlying mechanisms of our recently optimized Chinese herbal formula Yangyinjiedu (YYJD) against lung cancer. YYJD significantly inhibits the proliferation of lung cancer cell lines (95-D, A549, H460 and H1975) by inducing cell cycle arrest and senescence in a dose-dependent manner. In particular, YYJD induces significant G2/M phase arrest and inhibits the colony formation of lung cancer cells. Moreover, we found that administration of YYJD could inhibit the growth of xenografted lung cancer cells in nude mice without loss in body weight. Our findings suggest that the herbal formula YYJD is a potential anti-tumor agent against lung cancer.

AB - Lung cancer represents a major cause of cancer-related death worldwide. Although various tactics and anti-tumor drugs have been used to improve curative effects, five-year survival rate of lung cancer patients remains poor. In this study, we investigated the action and underlying mechanisms of our recently optimized Chinese herbal formula Yangyinjiedu (YYJD) against lung cancer. YYJD significantly inhibits the proliferation of lung cancer cell lines (95-D, A549, H460 and H1975) by inducing cell cycle arrest and senescence in a dose-dependent manner. In particular, YYJD induces significant G2/M phase arrest and inhibits the colony formation of lung cancer cells. Moreover, we found that administration of YYJD could inhibit the growth of xenografted lung cancer cells in nude mice without loss in body weight. Our findings suggest that the herbal formula YYJD is a potential anti-tumor agent against lung cancer.

KW - cancer

KW - lungs

KW - medicine_Chinese

KW - mice

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:44201

U2 - 10.1038/s41598-017-05146-x

DO - 10.1038/s41598-017-05146-x

M3 - Article

SN - 2045-2322

VL - 7

JO - Scientific Reports

JF - Scientific Reports

M1 - 4984

ER -

Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer

Abstract

Open Access - Access Right Statement

Keywords

UN SDGs

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