Heronamycin A : a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.

Ritesh Raju, Andrew M. Piggott, Zeinab Khalil, Paul V. Bernhardt, Robert J. Capon

    Research output: Contribution to journalArticlepeer-review

    24 Citations (Scopus)

    Abstract

    Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0392) isolated from sediment collected off Heron Island, Queensland, Australia, yielded a new benzothiazine ansamycin, heronamycin A. The absolute stereostructure of heronamycin A was determined by detailed spectroscopic analysis and Xray crystallography. Heronamycin A exhibited modest antimicrobial activity against Bacillus subtilis strains ATCC 6051 and 6633 (IC50 = 18 and 14 lM, respectively).
    Original languageEnglish
    Pages (from-to)1063-1065
    Number of pages3
    JournalTetrahedron Letters
    Volume53
    Issue number9
    DOIs
    Publication statusPublished - 2012

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