Heronamycin A : a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.

Ritesh Raju; Andrew M. Piggott; Zeinab Khalil; Paul V. Bernhardt; Robert J. Capon

doi:10.1016/j.tetlet.2011.12.064

Heronamycin A : a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.

Ritesh Raju
, Andrew M. Piggott
, Zeinab Khalil
, Paul V. Bernhardt
, Robert J. Capon

School of Medicine

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0392) isolated from sediment collected off Heron Island, Queensland, Australia, yielded a new benzothiazine ansamycin, heronamycin A. The absolute stereostructure of heronamycin A was determined by detailed spectroscopic analysis and Xray crystallography. Heronamycin A exhibited modest antimicrobial activity against Bacillus subtilis strains ATCC 6051 and 6633 (IC50 = 18 and 14 lM, respectively).

Original language	English
Pages (from-to)	1063-1065
Number of pages	3
Journal	Tetrahedron Letters
Volume	53
Issue number	9
DOIs	https://doi.org/10.1016/j.tetlet.2011.12.064
Publication status	Published - 2012

Access to Document

10.1016/j.tetlet.2011.12.064

Cite this

@article{bbe6a7af5c5d49bf81cef91adb2a13c2,

title = "Heronamycin A : a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.",

abstract = "Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0392) isolated from sediment collected off Heron Island, Queensland, Australia, yielded a new benzothiazine ansamycin, heronamycin A. The absolute stereostructure of heronamycin A was determined by detailed spectroscopic analysis and Xray crystallography. Heronamycin A exhibited modest antimicrobial activity against Bacillus subtilis strains ATCC 6051 and 6633 (IC50 = 18 and 14 lM, respectively).",

author = "Ritesh Raju and Piggott, \{Andrew M.\} and Zeinab Khalil and Bernhardt, \{Paul V.\} and Capon, \{Robert J.\}",

year = "2012",

doi = "10.1016/j.tetlet.2011.12.064",

language = "English",

volume = "53",

pages = "1063--1065",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier",

number = "9",

}

TY - JOUR

T1 - Heronamycin A : a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.

AU - Raju, Ritesh

AU - Piggott, Andrew M.

AU - Khalil, Zeinab

AU - Bernhardt, Paul V.

AU - Capon, Robert J.

PY - 2012

Y1 - 2012

N2 - Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0392) isolated from sediment collected off Heron Island, Queensland, Australia, yielded a new benzothiazine ansamycin, heronamycin A. The absolute stereostructure of heronamycin A was determined by detailed spectroscopic analysis and Xray crystallography. Heronamycin A exhibited modest antimicrobial activity against Bacillus subtilis strains ATCC 6051 and 6633 (IC50 = 18 and 14 lM, respectively).

AB - Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0392) isolated from sediment collected off Heron Island, Queensland, Australia, yielded a new benzothiazine ansamycin, heronamycin A. The absolute stereostructure of heronamycin A was determined by detailed spectroscopic analysis and Xray crystallography. Heronamycin A exhibited modest antimicrobial activity against Bacillus subtilis strains ATCC 6051 and 6633 (IC50 = 18 and 14 lM, respectively).

UR - http://handle.uws.edu.au:8081/1959.7/547312

U2 - 10.1016/j.tetlet.2011.12.064

DO - 10.1016/j.tetlet.2011.12.064

M3 - Article

SN - 0040-4039

VL - 53

SP - 1063

EP - 1065

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 9

ER -

Heronamycin A : a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.

Abstract

Access to Document

Other files and links

Fingerprint

Cite this