Heterogeneity of Tregs and the complexity in the IL-12 cytokine family signaling in driving T-cell immune responses in atherosclerotic vessels

Dimitry A. Chistiakov; Yuri V. Bobryshev; Alexander N. Orekhov

doi:10.1016/j.molimm.2015.01.013

Heterogeneity of Tregs and the complexity in the IL-12 cytokine family signaling in driving T-cell immune responses in atherosclerotic vessels

Dimitry A. Chistiakov
, Yuri V. Bobryshev
, Alexander N. Orekhov

Western Sydney University

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The importance of immune inflammation in the development and progression of atherosclerotic lesions is well recognized. Accumulated evidence shows striking features of heterogeneity of regulatory T cells (Tregs) and the importance of the IL-12 cytokine family in regulation of Tregs in atherogenesis. The present review briefly summarized the current knowledge about the impact of the IL-12 cytokine family in regulation of immune processes in atherogenesis.

Original language	English
Pages (from-to)	133-138
Number of pages	6
Journal	Molecular Immunology
Volume	65
Issue number	1
DOIs	https://doi.org/10.1016/j.molimm.2015.01.013
Publication status	Published - 2015

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title = "Heterogeneity of Tregs and the complexity in the IL-12 cytokine family signaling in driving T-cell immune responses in atherosclerotic vessels",

abstract = "The importance of immune inflammation in the development and progression of atherosclerotic lesions is well recognized. Accumulated evidence shows striking features of heterogeneity of regulatory T cells (Tregs) and the importance of the IL-12 cytokine family in regulation of Tregs in atherogenesis. The present review briefly summarized the current knowledge about the impact of the IL-12 cytokine family in regulation of immune processes in atherogenesis.",

author = "Chistiakov, \{Dimitry A.\} and Bobryshev, \{Yuri V.\} and Orekhov, \{Alexander N.\}",

year = "2015",

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journal = "Molecular Immunology",

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T1 - Heterogeneity of Tregs and the complexity in the IL-12 cytokine family signaling in driving T-cell immune responses in atherosclerotic vessels

AU - Chistiakov, Dimitry A.

AU - Bobryshev, Yuri V.

AU - Orekhov, Alexander N.

PY - 2015

Y1 - 2015

N2 - The importance of immune inflammation in the development and progression of atherosclerotic lesions is well recognized. Accumulated evidence shows striking features of heterogeneity of regulatory T cells (Tregs) and the importance of the IL-12 cytokine family in regulation of Tregs in atherogenesis. The present review briefly summarized the current knowledge about the impact of the IL-12 cytokine family in regulation of immune processes in atherogenesis.

AB - The importance of immune inflammation in the development and progression of atherosclerotic lesions is well recognized. Accumulated evidence shows striking features of heterogeneity of regulatory T cells (Tregs) and the importance of the IL-12 cytokine family in regulation of Tregs in atherogenesis. The present review briefly summarized the current knowledge about the impact of the IL-12 cytokine family in regulation of immune processes in atherogenesis.

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:41957

U2 - 10.1016/j.molimm.2015.01.013

DO - 10.1016/j.molimm.2015.01.013

M3 - Article

SN - 0161-5890

VL - 65

SP - 133

EP - 138

JO - Molecular Immunology

JF - Molecular Immunology

IS - 1

ER -

Heterogeneity of Tregs and the complexity in the IL-12 cytokine family signaling in driving T-cell immune responses in atherosclerotic vessels

Abstract

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