Abstract
In states of insulopaenic hyperglycaemia, counter-regulatory hormone (CRH) excess is a driver of ketogenesis and thus diabetic ketoacidosis. We present a case of hyperglycaemic hyperosmolar state in a patient with type 1 diabetes mellitus, associated with a mixed drug overdose including agents with documented CRH suppressive effects. We postulate that the drugs taken in overdose protected against diabetic ketoacidosis, and suggest further investigation of pharmacological therapies aimed at inhibiting CRH responses which may protect against this life-threatening complication in patients with type 1 diabetes.
| Original language | English |
|---|---|
| Pages (from-to) | 54-56 |
| Number of pages | 3 |
| Journal | Practical Diabetes |
| Volume | 33 |
| Issue number | 2 |
| Publication status | Published - 1 Mar 2016 |
Bibliographical note
Publisher Copyright:Copyright © 2016 John Wiley & Sons.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- diabetes
- diabetic acidosis
- hyperglycemia
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