Abstract
Kanatsu-Shinohara and colleagues continue to reveal the secrets of the rare mammalian spermatogonial stem cells. Their most recent study offers a new approach by applying principles from hematopoietic stem cell research to demonstrate that cells which form a cobblestone- like underlay beneath testicular somatic cells in culture are spermatogonial stem cells. Utilization of mouse models and cell cultures shows how the chemokine, CXCL12, fits into the signalling cascade which governs the fate of these cells and hence is essential to male fertility.
| Original language | English |
|---|---|
| Pages (from-to) | 214-215 |
| Number of pages | 2 |
| Journal | Asian Journal of Andrology |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2013 |
Open Access - Access Right Statement
This is an open access journal and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License (https://creativecommons.org/licenses/by-nc-sa/4.0/), which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.Keywords
- mice
- spermatogenesis
- stem cells
- testis