HIV/AIDS-related mortality in Africa and Asia : evidence from INDEPTH health and demographic surveillance system sites

P. Kim Streatfield; Wasif A. Khan; Abbas Bhuiya; Syed M. A. Hanifi; Nurul Alam; Ourohiré Millogo; Ali Sié; Pascal Zabré; Clementine Rossier; Abdramane B. Soura; Bassirou Bonfoh; Siaka Kone; Eliezer K. Ngoran; Juerg Utzinger; Semaw F. Abera; Yohannes A. Melaku; Berhe Weldearegawi; Pierre Gomez; Momodou Jasseh; Patrick Ansah; Daniel Azongo; Felix Kondayire; Abraham Oduro; Alberta Amu; Margaret Gyapong; Odette Kwarteng; Shashi Kant; Chandrakant S. Pandav; Sanjay K. Rai; Sanjay Juvekar; Veena Muralidharan; Abdul Wahab; Siswanto Wilopo; Evasius Bauni; George Mochamah; Carolyne Ndila; Thomas N. Williams; Sammy Khagayi; Kayla F. Laserson; Amek Nyaguara; Anna M. Van Eijk; Alex Ezeh; Catherine Kyobutungi; Marylene Wamukoya; Menard Chihana; Amelia Crampin; Alison Price; Valérie Delaunay; Aldiouma Diallo; Laetitia Douillot; Cheikh Sokhna; F. Xavier Gómez-Olivé; Paul Mee; Stephen M. Tollman; Kobus Herbst; Joël Mossong; Nguyen T. K. Chuc; Samuelina S. Arthur; Osman A. Sankoh; Peter Byass

doi:10.3402/gha.v7.25370

HIV/AIDS-related mortality in Africa and Asia : evidence from INDEPTH health and demographic surveillance system sites

P. Kim Streatfield, Wasif A. Khan, Abbas Bhuiya, Syed M. A. Hanifi, Nurul Alam, Ourohiré Millogo, Ali Sié, Pascal Zabré, Clementine Rossier, Abdramane B. Soura, Bassirou Bonfoh, Siaka Kone, Eliezer K. Ngoran, Juerg Utzinger, Semaw F. Abera, Yohannes A. Melaku, Berhe Weldearegawi, Pierre Gomez, Momodou Jasseh, Patrick AnsahDaniel Azongo, Felix Kondayire, Abraham Oduro, Alberta Amu, Margaret Gyapong, Odette Kwarteng, Shashi Kant, Chandrakant S. Pandav, Sanjay K. Rai, Sanjay Juvekar, Veena Muralidharan, Abdul Wahab, Siswanto Wilopo, Evasius Bauni, George Mochamah, Carolyne Ndila, Thomas N. Williams, Sammy Khagayi, Kayla F. Laserson, Amek Nyaguara, Anna M. Van Eijk, Alex Ezeh, Catherine Kyobutungi, Marylene Wamukoya, Menard Chihana, Amelia Crampin, Alison Price, Valérie Delaunay, Aldiouma Diallo, Laetitia Douillot, Cheikh Sokhna, F. Xavier Gómez-Olivé, Paul Mee, Stephen M. Tollman, Kobus Herbst, Joël Mossong, Nguyen T. K. Chuc, Samuelina S. Arthur, Osman A. Sankoh, Peter Byass

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

Background: As the HIV/AIDS pandemic has evolved over recent decades, Africa has been the most affected region, even though a large proportion of HIV/AIDS deaths have not been documented at the individual level. Systematic application of verbal autopsy (VA) methods in defined populations provides an opportunity to assess the mortality burden of the pandemic from individual data. Objective: To present standardised comparisons of HIV/AIDS-related mortality at sites across Africa and Asia, including closely related causes of death such as pulmonary tuberculosis (PTB) and pneumonia. Design: Deaths related to HIV/AIDS were extracted from individual demographic and VA data from 22 INDEPTH sites across Africa and Asia. VA data were standardised to WHO 2012 standard causes of death assigned using the InterVA-4 model. Between-site comparisons of mortality rates were standardised using the INDEPTH 2013 standard population. Results: The dataset covered a total of 10,773 deaths attributed to HIV/AIDS, observed over 12,204,043 person-years. HIV/AIDS-related mortality fractions and mortality rates varied widely across Africa and Asia, with highest burdens in eastern and southern Africa, and lowest burdens in Asia. There was evidence of rapidly declining rates at the sites with the heaviest burdens. HIV/AIDS mortality was also strongly related to PTB mortality. On a country basis, there were strong similarities between HIV/AIDS mortality rates at INDEPTH sites and those derived from modelled estimates. Conclusions: Measuring HIV/AIDS-related mortality continues to be a challenging issue, all the more so as anti-retroviral treatment programmes alleviate mortality risks. The congruence between these results and other estimates adds plausibility to both approaches. These data, covering some of the highest mortality observed during the pandemic, will be an important baseline for understanding the future decline of HIV/AIDS.

Original language	English
Article number	25370
Number of pages	11
Journal	Global Health Action
Volume	7
Issue number	1
DOIs	https://doi.org/10.3402/gha.v7.25370
Publication status	Published - 2014

Open Access - Access Right Statement

© 2014 INDEPTH Network. This is an Open Access article distributed under the terms of the Creative Commons CC-BY 4.0 License (http://creativecommons.org/licenses/by/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license.

Keywords

AIDS (disease)
HIV (viruses)
mortality
tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3402/gha.v7.25370

Cite this

Kim Streatfield, P., Khan, W. A., Bhuiya, A., Hanifi, S. M. A., Alam, N., Millogo, O., Sié, A., Zabré, P., Rossier, C., Soura, A. B., Bonfoh, B., Kone, S., Ngoran, E. K., Utzinger, J., Abera, S. F., Melaku, Y. A., Weldearegawi, B., Gomez, P., Jasseh, M., ... Byass, P. (2014). HIV/AIDS-related mortality in Africa and Asia : evidence from INDEPTH health and demographic surveillance system sites. Global Health Action, 7(1), Article 25370. https://doi.org/10.3402/gha.v7.25370

@article{370d614913014dc39412d1f0677320f7,

title = "HIV/AIDS-related mortality in Africa and Asia : evidence from INDEPTH health and demographic surveillance system sites",

abstract = "Background: As the HIV/AIDS pandemic has evolved over recent decades, Africa has been the most affected region, even though a large proportion of HIV/AIDS deaths have not been documented at the individual level. Systematic application of verbal autopsy (VA) methods in defined populations provides an opportunity to assess the mortality burden of the pandemic from individual data. Objective: To present standardised comparisons of HIV/AIDS-related mortality at sites across Africa and Asia, including closely related causes of death such as pulmonary tuberculosis (PTB) and pneumonia. Design: Deaths related to HIV/AIDS were extracted from individual demographic and VA data from 22 INDEPTH sites across Africa and Asia. VA data were standardised to WHO 2012 standard causes of death assigned using the InterVA-4 model. Between-site comparisons of mortality rates were standardised using the INDEPTH 2013 standard population. Results: The dataset covered a total of 10,773 deaths attributed to HIV/AIDS, observed over 12,204,043 person-years. HIV/AIDS-related mortality fractions and mortality rates varied widely across Africa and Asia, with highest burdens in eastern and southern Africa, and lowest burdens in Asia. There was evidence of rapidly declining rates at the sites with the heaviest burdens. HIV/AIDS mortality was also strongly related to PTB mortality. On a country basis, there were strong similarities between HIV/AIDS mortality rates at INDEPTH sites and those derived from modelled estimates. Conclusions: Measuring HIV/AIDS-related mortality continues to be a challenging issue, all the more so as anti-retroviral treatment programmes alleviate mortality risks. The congruence between these results and other estimates adds plausibility to both approaches. These data, covering some of the highest mortality observed during the pandemic, will be an important baseline for understanding the future decline of HIV/AIDS.",

keywords = "AIDS (disease), HIV (viruses), mortality, tuberculosis",

author = "{Kim Streatfield}, P. and Khan, {Wasif A.} and Abbas Bhuiya and Hanifi, {Syed M. A.} and Nurul Alam and Ourohir{\'e} Millogo and Ali Si{\'e} and Pascal Zabr{\'e} and Clementine Rossier and Soura, {Abdramane B.} and Bassirou Bonfoh and Siaka Kone and Ngoran, {Eliezer K.} and Juerg Utzinger and Abera, {Semaw F.} and Melaku, {Yohannes A.} and Berhe Weldearegawi and Pierre Gomez and Momodou Jasseh and Patrick Ansah and Daniel Azongo and Felix Kondayire and Abraham Oduro and Alberta Amu and Margaret Gyapong and Odette Kwarteng and Shashi Kant and Pandav, {Chandrakant S.} and Rai, {Sanjay K.} and Sanjay Juvekar and Veena Muralidharan and Abdul Wahab and Siswanto Wilopo and Evasius Bauni and George Mochamah and Carolyne Ndila and Williams, {Thomas N.} and Sammy Khagayi and Laserson, {Kayla F.} and Amek Nyaguara and {Van Eijk}, {Anna M.} and Alex Ezeh and Catherine Kyobutungi and Marylene Wamukoya and Menard Chihana and Amelia Crampin and Alison Price and Val{\'e}rie Delaunay and Aldiouma Diallo and Laetitia Douillot and Cheikh Sokhna and {Xavier G{\'o}mez-Oliv{\'e}}, F. and Paul Mee and Tollman, {Stephen M.} and Kobus Herbst and Jo{\"e}l Mossong and Chuc, {Nguyen T. K.} and Arthur, {Samuelina S.} and Sankoh, {Osman A.} and Peter Byass",

year = "2014",

doi = "10.3402/gha.v7.25370",

language = "English",

volume = "7",

journal = "Global Health Action",

issn = "1654-9716",

publisher = "Taylor & Francis",

number = "1",

}

Kim Streatfield, P, Khan, WA, Bhuiya, A, Hanifi, SMA, Alam, N, Millogo, O, Sié, A, Zabré, P, Rossier, C, Soura, AB, Bonfoh, B, Kone, S, Ngoran, EK, Utzinger, J, Abera, SF, Melaku, YA, Weldearegawi, B, Gomez, P, Jasseh, M, Ansah, P, Azongo, D, Kondayire, F, Oduro, A, Amu, A, Gyapong, M, Kwarteng, O, Kant, S, Pandav, CS, Rai, SK, Juvekar, S, Muralidharan, V, Wahab, A, Wilopo, S, Bauni, E, Mochamah, G, Ndila, C, Williams, TN, Khagayi, S, Laserson, KF, Nyaguara, A, Van Eijk, AM, Ezeh, A, Kyobutungi, C, Wamukoya, M, Chihana, M, Crampin, A, Price, A, Delaunay, V, Diallo, A, Douillot, L, Sokhna, C, Xavier Gómez-Olivé, F, Mee, P, Tollman, SM, Herbst, K, Mossong, J, Chuc, NTK, Arthur, SS, Sankoh, OA & Byass, P 2014, 'HIV/AIDS-related mortality in Africa and Asia : evidence from INDEPTH health and demographic surveillance system sites', Global Health Action, vol. 7, no. 1, 25370. https://doi.org/10.3402/gha.v7.25370

TY - JOUR

T1 - HIV/AIDS-related mortality in Africa and Asia : evidence from INDEPTH health and demographic surveillance system sites

AU - Kim Streatfield, P.

AU - Khan, Wasif A.

AU - Bhuiya, Abbas

AU - Hanifi, Syed M. A.

AU - Alam, Nurul

AU - Millogo, Ourohiré

AU - Sié, Ali

AU - Zabré, Pascal

AU - Rossier, Clementine

AU - Soura, Abdramane B.

AU - Bonfoh, Bassirou

AU - Kone, Siaka

AU - Ngoran, Eliezer K.

AU - Utzinger, Juerg

AU - Abera, Semaw F.

AU - Melaku, Yohannes A.

AU - Weldearegawi, Berhe

AU - Gomez, Pierre

AU - Jasseh, Momodou

AU - Ansah, Patrick

AU - Azongo, Daniel

AU - Kondayire, Felix

AU - Oduro, Abraham

AU - Amu, Alberta

AU - Gyapong, Margaret

AU - Kwarteng, Odette

AU - Kant, Shashi

AU - Pandav, Chandrakant S.

AU - Rai, Sanjay K.

AU - Juvekar, Sanjay

AU - Muralidharan, Veena

AU - Wahab, Abdul

AU - Wilopo, Siswanto

AU - Bauni, Evasius

AU - Mochamah, George

AU - Ndila, Carolyne

AU - Williams, Thomas N.

AU - Khagayi, Sammy

AU - Laserson, Kayla F.

AU - Nyaguara, Amek

AU - Van Eijk, Anna M.

AU - Ezeh, Alex

AU - Kyobutungi, Catherine

AU - Wamukoya, Marylene

AU - Chihana, Menard

AU - Crampin, Amelia

AU - Price, Alison

AU - Delaunay, Valérie

AU - Diallo, Aldiouma

AU - Douillot, Laetitia

AU - Sokhna, Cheikh

AU - Xavier Gómez-Olivé, F.

AU - Mee, Paul

AU - Tollman, Stephen M.

AU - Herbst, Kobus

AU - Mossong, Joël

AU - Chuc, Nguyen T. K.

AU - Arthur, Samuelina S.

AU - Sankoh, Osman A.

AU - Byass, Peter

PY - 2014

Y1 - 2014

N2 - Background: As the HIV/AIDS pandemic has evolved over recent decades, Africa has been the most affected region, even though a large proportion of HIV/AIDS deaths have not been documented at the individual level. Systematic application of verbal autopsy (VA) methods in defined populations provides an opportunity to assess the mortality burden of the pandemic from individual data. Objective: To present standardised comparisons of HIV/AIDS-related mortality at sites across Africa and Asia, including closely related causes of death such as pulmonary tuberculosis (PTB) and pneumonia. Design: Deaths related to HIV/AIDS were extracted from individual demographic and VA data from 22 INDEPTH sites across Africa and Asia. VA data were standardised to WHO 2012 standard causes of death assigned using the InterVA-4 model. Between-site comparisons of mortality rates were standardised using the INDEPTH 2013 standard population. Results: The dataset covered a total of 10,773 deaths attributed to HIV/AIDS, observed over 12,204,043 person-years. HIV/AIDS-related mortality fractions and mortality rates varied widely across Africa and Asia, with highest burdens in eastern and southern Africa, and lowest burdens in Asia. There was evidence of rapidly declining rates at the sites with the heaviest burdens. HIV/AIDS mortality was also strongly related to PTB mortality. On a country basis, there were strong similarities between HIV/AIDS mortality rates at INDEPTH sites and those derived from modelled estimates. Conclusions: Measuring HIV/AIDS-related mortality continues to be a challenging issue, all the more so as anti-retroviral treatment programmes alleviate mortality risks. The congruence between these results and other estimates adds plausibility to both approaches. These data, covering some of the highest mortality observed during the pandemic, will be an important baseline for understanding the future decline of HIV/AIDS.

AB - Background: As the HIV/AIDS pandemic has evolved over recent decades, Africa has been the most affected region, even though a large proportion of HIV/AIDS deaths have not been documented at the individual level. Systematic application of verbal autopsy (VA) methods in defined populations provides an opportunity to assess the mortality burden of the pandemic from individual data. Objective: To present standardised comparisons of HIV/AIDS-related mortality at sites across Africa and Asia, including closely related causes of death such as pulmonary tuberculosis (PTB) and pneumonia. Design: Deaths related to HIV/AIDS were extracted from individual demographic and VA data from 22 INDEPTH sites across Africa and Asia. VA data were standardised to WHO 2012 standard causes of death assigned using the InterVA-4 model. Between-site comparisons of mortality rates were standardised using the INDEPTH 2013 standard population. Results: The dataset covered a total of 10,773 deaths attributed to HIV/AIDS, observed over 12,204,043 person-years. HIV/AIDS-related mortality fractions and mortality rates varied widely across Africa and Asia, with highest burdens in eastern and southern Africa, and lowest burdens in Asia. There was evidence of rapidly declining rates at the sites with the heaviest burdens. HIV/AIDS mortality was also strongly related to PTB mortality. On a country basis, there were strong similarities between HIV/AIDS mortality rates at INDEPTH sites and those derived from modelled estimates. Conclusions: Measuring HIV/AIDS-related mortality continues to be a challenging issue, all the more so as anti-retroviral treatment programmes alleviate mortality risks. The congruence between these results and other estimates adds plausibility to both approaches. These data, covering some of the highest mortality observed during the pandemic, will be an important baseline for understanding the future decline of HIV/AIDS.

KW - AIDS (disease)

KW - HIV (viruses)

KW - mortality

KW - tuberculosis

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:48160

U2 - 10.3402/gha.v7.25370

DO - 10.3402/gha.v7.25370

M3 - Article

SN - 1654-9716

VL - 7

JO - Global Health Action

JF - Global Health Action

IS - 1

M1 - 25370

ER -

HIV/AIDS-related mortality in Africa and Asia : evidence from INDEPTH health and demographic surveillance system sites

Abstract

Open Access - Access Right Statement

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this