Holistic prevention and management of physical health side-effects of psychotropic medication: second report of the Lancet Psychiatry Physical Health Commission

Sean Halstead; Chloe X. Yap; Nicola Warren; Sri Mahavir Agarwal; Bodyl A. Brand; Sherry Kit Wa Chan; Andrea Cipriani; Christoph U. Correll; Nicolas Crossley; Enrico D'Ambrosio; Robin Emsley; Joseph Firth; Fiona Gaughran; Siobhan Gee; Margaret Hahn; Joseph F. Hayes; Adrian Heald; Oliver D. Howes; John M. Kane; Maria Kapi; Stefan Leucht; Nicholas Meyer; Brian O'Donoghue; Emmanuel Okeke; Benjamin I. Perry; Marco Solmi; Iris E. Sommer; Vivek Srivastava; Heidi Taipale; David Taylor; Jari Tiihonen; Allan H. Young; the Lancet Psychiatry Physical Health Commission Consortium; Robert A. McCutcheon; Dan Siskind; Toby Pillinger; Joseph Firth; Jerome Sarris; et al.

doi:10.1016/S2215-0366(25)00162-2

Holistic prevention and management of physical health side-effects of psychotropic medication: second report of the Lancet Psychiatry Physical Health Commission

Sean Halstead
, Chloe X. Yap
, Nicola Warren
, Sri Mahavir Agarwal
, Bodyl A. Brand
, Sherry Kit Wa Chan
, Andrea Cipriani
, Christoph U. Correll
, Nicolas Crossley
, Enrico D'Ambrosio
, Robin Emsley
, Joseph Firth
, Fiona Gaughran
, Siobhan Gee
, Margaret Hahn
, Joseph F. Hayes
, Adrian Heald
, Oliver D. Howes
, John M. Kane
, Maria Kapi

Stefan Leucht, Nicholas Meyer, Brian O'Donoghue, Emmanuel Okeke, Benjamin I. Perry, Marco Solmi, Iris E. Sommer, Vivek Srivastava, Heidi Taipale, David Taylor, Jari Tiihonen, Allan H. Young, the Lancet Psychiatry Physical Health Commission Consortium, Robert A. McCutcheon, Dan Siskind, Toby Pillinger, Joseph Firth, Jerome Sarris, et al.

NICM Health Research Institute

Metro South Addiction and Mental Health Service
University of Queensland
University of Oxford
University of Toronto
The University of Hong Kong
Oxford Health NHS Foundation Trust
Zucker Hillside Hospital
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Northwell Health System
Charité – Universitätsmedizin Berlin
German Center for Mental Health (DZPG)
Pontificia Universidad Católica de Chile
University of Bari
King's College London
Stellenbosch University
University of Manchester
Manchester University NHS Foundation Trust
South London and Maudsley NHS Foundation Trust
University of Copenhagen
University College London
North London NHS Foundation Trust
Northern Care Alliance NHS Group
Technical University of Munich
University College London Hospitals NHS Foundation Trust
University College Dublin
University of Birmingham
Birmingham Women's and Children's NHS Foundation Trust
University of Ottawa
University of Groningen
Guy's and St Thomas' NHS Foundation Trust
PanLondon Acute Medicine Network
University of Eastern Finland
Karolinska Institutet
University of Helsinki
Imperial College London
University of Queensland
Manchester Academic Health Science Centre

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Background: To counter modern medicine’s tendency to fragment health care into silos, people with mental illness should have access to holistic care that protects both physical and mental health. Antipsychotics, mood stabilisers, and antidepressants are an integral component of evidenced-based treatment for mental disorders, and reduce morbidity and mortality at a population level. However, the various medications within these classes of psychotropic drugs lead to a range of important side-effects across multiple physiological systems. Side-effects can impact physical health and quality of life and lead to non-adherence, compromising the associated benefits of treatment.

Original language	English
Pages (from-to)	673-699
Number of pages	27
Journal	The Lancet Psychiatry
Volume	12
Issue number	9
DOIs	https://doi.org/10.1016/S2215-0366(25)00162-2
Publication status	Published - Sept 2025

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Halstead, S., Yap, C. X., Warren, N., Agarwal, S. M., Brand, B. A., Chan, S. K. W., Cipriani, A., Correll, C. U., Crossley, N., D'Ambrosio, E., Emsley, R., Firth, J., Gaughran, F., Gee, S., Hahn, M., Hayes, J. F., Heald, A., Howes, O. D., Kane, J. M., ... et al. (2025). Holistic prevention and management of physical health side-effects of psychotropic medication: second report of the Lancet Psychiatry Physical Health Commission. The Lancet Psychiatry, 12(9), 673-699. https://doi.org/10.1016/S2215-0366(25)00162-2

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title = "Holistic prevention and management of physical health side-effects of psychotropic medication: second report of the Lancet Psychiatry Physical Health Commission",

abstract = "Background: To counter modern medicine{\textquoteright}s tendency to fragment health care into silos, people with mental illness should have access to holistic care that protects both physical and mental health. Antipsychotics, mood stabilisers, and antidepressants are an integral component of evidenced-based treatment for mental disorders, and reduce morbidity and mortality at a population level. However, the various medications within these classes of psychotropic drugs lead to a range of important side-effects across multiple physiological systems. Side-effects can impact physical health and quality of life and lead to non-adherence, compromising the associated benefits of treatment. ",

author = "Sean Halstead and Yap, \{Chloe X.\} and Nicola Warren and Agarwal, \{Sri Mahavir\} and Brand, \{Bodyl A.\} and Chan, \{Sherry Kit Wa\} and Andrea Cipriani and Correll, \{Christoph U.\} and Nicolas Crossley and Enrico D'Ambrosio and Robin Emsley and Joseph Firth and Fiona Gaughran and Siobhan Gee and Margaret Hahn and Hayes, \{Joseph F.\} and Adrian Heald and Howes, \{Oliver D.\} and Kane, \{John M.\} and Maria Kapi and Stefan Leucht and Nicholas Meyer and Brian O'Donoghue and Emmanuel Okeke and Perry, \{Benjamin I.\} and Marco Solmi and Sommer, \{Iris E.\} and Vivek Srivastava and Heidi Taipale and David Taylor and Jari Tiihonen and Young, \{Allan H.\} and \{the Lancet Psychiatry Physical Health Commission Consortium\} and McCutcheon, \{Robert A.\} and Dan Siskind and Toby Pillinger and Joseph Firth and Jerome Sarris and \{et al.\}",

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doi = "10.1016/S2215-0366(25)00162-2",

language = "English",

volume = "12",

pages = "673--699",

journal = "The Lancet Psychiatry",

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Halstead, S, Yap, CX, Warren, N, Agarwal, SM, Brand, BA, Chan, SKW, Cipriani, A, Correll, CU, Crossley, N, D'Ambrosio, E, Emsley, R, Firth, J, Gaughran, F, Gee, S, Hahn, M, Hayes, JF, Heald, A, Howes, OD, Kane, JM, Kapi, M, Leucht, S, Meyer, N, O'Donoghue, B, Okeke, E, Perry, BI, Solmi, M, Sommer, IE, Srivastava, V, Taipale, H, Taylor, D, Tiihonen, J, Young, AH, the Lancet Psychiatry Physical Health Commission Consortium, McCutcheon, RA, Siskind, D, Pillinger, T, Firth, J, Sarris, J & et al. 2025, 'Holistic prevention and management of physical health side-effects of psychotropic medication: second report of the Lancet Psychiatry Physical Health Commission', The Lancet Psychiatry, vol. 12, no. 9, pp. 673-699. https://doi.org/10.1016/S2215-0366(25)00162-2

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AU - Halstead, Sean

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AU - Warren, Nicola

AU - Agarwal, Sri Mahavir

AU - Brand, Bodyl A.

AU - Chan, Sherry Kit Wa

AU - Cipriani, Andrea

AU - Correll, Christoph U.

AU - Crossley, Nicolas

AU - D'Ambrosio, Enrico

AU - Emsley, Robin

AU - Firth, Joseph

AU - Gaughran, Fiona

AU - Gee, Siobhan

AU - Hahn, Margaret

AU - Hayes, Joseph F.

AU - Heald, Adrian

AU - Howes, Oliver D.

AU - Kane, John M.

AU - Kapi, Maria

AU - Leucht, Stefan

AU - Meyer, Nicholas

AU - O'Donoghue, Brian

AU - Okeke, Emmanuel

AU - Perry, Benjamin I.

AU - Solmi, Marco

AU - Sommer, Iris E.

AU - Srivastava, Vivek

AU - Taipale, Heidi

AU - Taylor, David

AU - Tiihonen, Jari

AU - Young, Allan H.

AU - the Lancet Psychiatry Physical Health Commission Consortium,

AU - McCutcheon, Robert A.

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AU - Firth, Joseph

AU - Sarris, Jerome

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AB - Background: To counter modern medicine’s tendency to fragment health care into silos, people with mental illness should have access to holistic care that protects both physical and mental health. Antipsychotics, mood stabilisers, and antidepressants are an integral component of evidenced-based treatment for mental disorders, and reduce morbidity and mortality at a population level. However, the various medications within these classes of psychotropic drugs lead to a range of important side-effects across multiple physiological systems. Side-effects can impact physical health and quality of life and lead to non-adherence, compromising the associated benefits of treatment.

UR - https://www.scopus.com/pages/publications/105013131582

UR - https://go.openathens.net/redirector/westernsydney.edu.au?url=https://doi.org/10.1016/S2215-0366(25)00162-2

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DO - 10.1016/S2215-0366(25)00162-2

M3 - Article

AN - SCOPUS:105013131582

SN - 2215-0366

VL - 12

SP - 673

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JO - The Lancet Psychiatry

JF - The Lancet Psychiatry

IS - 9

ER -

Holistic prevention and management of physical health side-effects of psychotropic medication: second report of the Lancet Psychiatry Physical Health Commission

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