TY - JOUR
T1 - How can Australia integrate routine genetic sequencing in oncology : a qualitative study through an implementation science lens
AU - O’Shea, R.
AU - Rankin, N. M.
AU - Kentwell, M.
AU - Gleeson, M.
AU - Salmon, L.
AU - Tucker, K. M.
AU - Lewis, Sarah
AU - Taylor, N.
PY - 2020
Y1 - 2020
N2 - Purpose: This study sought to determine genetics and oncology specialists’ views of integrating BRCA1 and BRCA2 testing in epithelial ovarian and breast cancer into routine practice. Methods: Qualitative interviews were designed using the Consolidated Framework for Implementation Research. Questions included experiences or views of the BRCA testing processes, implementation needs of oncology health professionals, perceived challenges, and future ideas for interventions to integrate genetic testing into oncology. Results: Twenty-two participants were interviewed from twelve health organizations and four themes were identified: (1) embracing the shift to mainstream genetic testing, with the majority of participants viewing BRCA testing as clinically useful and routine use important for maintaining a patient centered process; (2) the need for communication networks and role delineation to integrate routine genetic testing; (3) factors that influence sustaining routine genetic testing, including ongoing training, resources and funding, real-world adaptation, system complexity, and champions; and (4) variation in system interventions for integratingÃÂ routine geneticÃÂ testingÃÂ align to organizational context. Conclusion: Findings illustrate the need for integrating genetic testing into routine oncology, and that adaptation of interventions and processes is essential to sustain a feasible model. An understanding of individual and organizational implementation factors will help to prepare for future integration of routine genetic testing in other cancers.
AB - Purpose: This study sought to determine genetics and oncology specialists’ views of integrating BRCA1 and BRCA2 testing in epithelial ovarian and breast cancer into routine practice. Methods: Qualitative interviews were designed using the Consolidated Framework for Implementation Research. Questions included experiences or views of the BRCA testing processes, implementation needs of oncology health professionals, perceived challenges, and future ideas for interventions to integrate genetic testing into oncology. Results: Twenty-two participants were interviewed from twelve health organizations and four themes were identified: (1) embracing the shift to mainstream genetic testing, with the majority of participants viewing BRCA testing as clinically useful and routine use important for maintaining a patient centered process; (2) the need for communication networks and role delineation to integrate routine genetic testing; (3) factors that influence sustaining routine genetic testing, including ongoing training, resources and funding, real-world adaptation, system complexity, and champions; and (4) variation in system interventions for integratingÃÂ routine geneticÃÂ testingÃÂ align to organizational context. Conclusion: Findings illustrate the need for integrating genetic testing into routine oncology, and that adaptation of interventions and processes is essential to sustain a feasible model. An understanding of individual and organizational implementation factors will help to prepare for future integration of routine genetic testing in other cancers.
UR - https://hdl.handle.net/1959.7/uws:74463
U2 - 10.1038/s41436-020-0838-x
DO - 10.1038/s41436-020-0838-x
M3 - Article
SN - 1530-0366
SN - 1098-3600
VL - 22
SP - 1507
EP - 1516
JO - Genetics in Medicine
JF - Genetics in Medicine
IS - 9
ER -