Human pancreatic islet progenitor cells demonstrate phenotypic plasticity in vitro

Maithili P. Dalvi; Malati R. Umrani; Mugdha V. Joglekar; Anandwardhan A. Hardikar

doi:10.1007/s12038-009-0071-x

Human pancreatic islet progenitor cells demonstrate phenotypic plasticity in vitro

Maithili P. Dalvi, Malati R. Umrani, Mugdha V. Joglekar, Anandwardhan A. Hardikar

Western Sydney University

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Phenotypic plasticity is a phenomenon that describes the occurrence of 2 or more distinct phenotypes under diverse conditions. This article discusses the work carried out over the past few years in understanding the potential of human pancreatic islet-derived progenitors for cell replacement therapy in diabetes. The phenotypic plasticity exhibited by pancreatic progenitors during reversible epithelial-to-mesenchymal transition (EMT) and possible role of microRNAs in regulation of this process is also presented herein.

Original language	English
Pages (from-to)	523-528
Number of pages	6
Journal	Journal of Biosciences
Volume	34
Issue number	4
DOIs	https://doi.org/10.1007/s12038-009-0071-x
Publication status	Published - 2009

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title = "Human pancreatic islet progenitor cells demonstrate phenotypic plasticity in vitro",

abstract = "Phenotypic plasticity is a phenomenon that describes the occurrence of 2 or more distinct phenotypes under diverse conditions. This article discusses the work carried out over the past few years in understanding the potential of human pancreatic islet-derived progenitors for cell replacement therapy in diabetes. The phenotypic plasticity exhibited by pancreatic progenitors during reversible epithelial-to-mesenchymal transition (EMT) and possible role of microRNAs in regulation of this process is also presented herein.",

author = "Dalvi, {Maithili P.} and Umrani, {Malati R.} and Joglekar, {Mugdha V.} and Hardikar, {Anandwardhan A.}",

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AU - Dalvi, Maithili P.

AU - Umrani, Malati R.

AU - Joglekar, Mugdha V.

AU - Hardikar, Anandwardhan A.

PY - 2009

Y1 - 2009

N2 - Phenotypic plasticity is a phenomenon that describes the occurrence of 2 or more distinct phenotypes under diverse conditions. This article discusses the work carried out over the past few years in understanding the potential of human pancreatic islet-derived progenitors for cell replacement therapy in diabetes. The phenotypic plasticity exhibited by pancreatic progenitors during reversible epithelial-to-mesenchymal transition (EMT) and possible role of microRNAs in regulation of this process is also presented herein.

AB - Phenotypic plasticity is a phenomenon that describes the occurrence of 2 or more distinct phenotypes under diverse conditions. This article discusses the work carried out over the past few years in understanding the potential of human pancreatic islet-derived progenitors for cell replacement therapy in diabetes. The phenotypic plasticity exhibited by pancreatic progenitors during reversible epithelial-to-mesenchymal transition (EMT) and possible role of microRNAs in regulation of this process is also presented herein.

UR - https://hdl.handle.net/1959.7/uws:76289

U2 - 10.1007/s12038-009-0071-x

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M3 - Article

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SN - 0973-7138

VL - 34

SP - 523

EP - 528

JO - Journal of Biosciences

JF - Journal of Biosciences

IS - 4

ER -

Human pancreatic islet progenitor cells demonstrate phenotypic plasticity in vitro

Abstract

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