Hydatidiform mole identification using non-invasive single-cell sequencing of fetal circulating extravillous trophoblasts isolated from maternal blood

C. Mangano, A. Doffini, C. Forcato, S. Boito, D. Lattuada, E. D. Giovannone, G. Buson, J. Hyett, T. J. Musci, F. R. Grati

Research output: Contribution to journalArticlepeer-review

Abstract

Partial hydatidiform mole (PHM) is typically triploid and derived from dispermic fertilization of the oocyte (P1P2M(P, paternal; M, maternal)). The majority of women with a molar pregnancy miscarry spontaneously during thefirst trimester. Accurate diagnosis is important due tothe associated risks of pre-eclampsia and gestational trophoblastic disease (GTD). However, a low rate of diagnosis persists as only 40% of cases are identified sonographically prior to uterine evacuation, and due to lack of histological confirmation. Additional accurate detection methods would overcome these limitations in current clinical practice.
Original languageEnglish
Pages (from-to)422-424
Number of pages3
JournalUltrasound in Obstetrics and Gynecology
Volume64
Issue number3
DOIs
Publication statusPublished - 2024

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