Hydrogen peroxide is a true first messenger

L. Holmquist, G. Stuchbury, Megan Steele, G. Münch

Research output: Chapter in Book / Conference PaperChapterpeer-review

15 Citations (Scopus)

Abstract

Hydrogen peroxide has been shown to act as a second messenger mediating intracellular redox-sensitive signal transduction. Here we show that hydrogen peroxide is also able to transmit pro-inflammatory signals from one cell to the other and that this action can be inhibited by extracellularly added catalase. If these data can be further substantiated, hydrogen peroxide might become as important as nitric oxide as a small molecule intercellular (first) messenger.

Original languageEnglish
Title of host publicationNeuropsychiatric Disorders An Integrative Approach
PublisherSpringer Wien
Pages39-41
Number of pages3
Edition72
ISBN (Print)9783211735732
DOIs
Publication statusPublished - 2007
Externally publishedYes

Publication series

NameJournal of Neural Transmission, Supplementa
Number72
ISSN (Print)0303-6995

Keywords

  • advanced glycation endproducts
  • hydrogen peroxide
  • Inflammation
  • lipopolysaccharide
  • nitric oxide
  • redox-sensitive signaling

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