Hyperechogenicity of the substantia nigra in Parkinson’s disease : insights from two brothers with markedly different disease durations

Julie M. Hall; Matthew J. Georgiades; Deborah A. Hammond; Xiaoting Feng; Ahmed A. Moustafa; Simon J. G. Lewis; Gabrielle Todd

doi:10.1155/2017/3673159

Hyperechogenicity of the substantia nigra in Parkinson’s disease : insights from two brothers with markedly different disease durations

Julie M. Hall, Matthew J. Georgiades, Deborah A. Hammond, Xiaoting Feng, Ahmed A. Moustafa, Simon J. G. Lewis, Gabrielle Todd

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

We present clinical features and substantia nigra morphology for two brothers with Parkinson’s disease (PD) aged 60 and 59 years. The brothers were diagnosed at 41 and 50 years of age, respectively. Both patients exhibited an abnormally large area of substantia nigra echogenicity bilaterally when viewed with transcranial ultrasound.The abnormality was similar in both brothers despite one having amuch longer disease duration than the other.These findings further highlight that transcranial ultrasound is not associated with severity of clinical symptoms, but it might assist in the diagnosis of PD provided that it is combined with other variables known to precede PD.

Original language	English
Article number	3673159
Number of pages	4
Journal	Case Reports in Neurological Medicine
Volume	2017
DOIs	https://doi.org/10.1155/2017/3673159
Publication status	Published - 2017

Open Access - Access Right Statement

© 2017 Julie M. Hall et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

Parkinson's disease
case studies
morphology
substantia nigra

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10.1155/2017/3673159

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title = "Hyperechogenicity of the substantia nigra in Parkinson{\textquoteright}s disease : insights from two brothers with markedly different disease durations",

abstract = "We present clinical features and substantia nigra morphology for two brothers with Parkinson{\textquoteright}s disease (PD) aged 60 and 59 years. The brothers were diagnosed at 41 and 50 years of age, respectively. Both patients exhibited an abnormally large area of substantia nigra echogenicity bilaterally when viewed with transcranial ultrasound.The abnormality was similar in both brothers despite one having amuch longer disease duration than the other.These findings further highlight that transcranial ultrasound is not associated with severity of clinical symptoms, but it might assist in the diagnosis of PD provided that it is combined with other variables known to precede PD.",

keywords = "Parkinson's disease, case studies, morphology, substantia nigra",

author = "Hall, {Julie M.} and Georgiades, {Matthew J.} and Hammond, {Deborah A.} and Xiaoting Feng and Moustafa, {Ahmed A.} and Lewis, {Simon J. G.} and Gabrielle Todd",

year = "2017",

doi = "10.1155/2017/3673159",

language = "English",

volume = "2017",

journal = "Case Reports in Neurological Medicine",

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AU - Hall, Julie M.

AU - Georgiades, Matthew J.

AU - Hammond, Deborah A.

AU - Feng, Xiaoting

AU - Moustafa, Ahmed A.

AU - Lewis, Simon J. G.

AU - Todd, Gabrielle

PY - 2017

Y1 - 2017

N2 - We present clinical features and substantia nigra morphology for two brothers with Parkinson’s disease (PD) aged 60 and 59 years. The brothers were diagnosed at 41 and 50 years of age, respectively. Both patients exhibited an abnormally large area of substantia nigra echogenicity bilaterally when viewed with transcranial ultrasound.The abnormality was similar in both brothers despite one having amuch longer disease duration than the other.These findings further highlight that transcranial ultrasound is not associated with severity of clinical symptoms, but it might assist in the diagnosis of PD provided that it is combined with other variables known to precede PD.

AB - We present clinical features and substantia nigra morphology for two brothers with Parkinson’s disease (PD) aged 60 and 59 years. The brothers were diagnosed at 41 and 50 years of age, respectively. Both patients exhibited an abnormally large area of substantia nigra echogenicity bilaterally when viewed with transcranial ultrasound.The abnormality was similar in both brothers despite one having amuch longer disease duration than the other.These findings further highlight that transcranial ultrasound is not associated with severity of clinical symptoms, but it might assist in the diagnosis of PD provided that it is combined with other variables known to precede PD.

KW - Parkinson's disease

KW - case studies

KW - morphology

KW - substantia nigra

UR - http://hdl.handle.net/1959.7/uws:41441

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DO - 10.1155/2017/3673159

M3 - Article

SN - 2090-6668

VL - 2017

JO - Case Reports in Neurological Medicine

JF - Case Reports in Neurological Medicine

M1 - 3673159

ER -

Hyperechogenicity of the substantia nigra in Parkinson’s disease : insights from two brothers with markedly different disease durations

Abstract

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Keywords

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