Hypersensitivity reactions to the polysorbate contained in recombinant erythropoietin and darbepoietin

Richard H. Steele; Sandhya Limaye; Bruce Cleland; Josephine Chow; Michael Suranyi

doi:10.1111/j.1440-1797.2005.00389.x

Hypersensitivity reactions to the polysorbate contained in recombinant erythropoietin and darbepoietin

Richard H. Steele, Sandhya Limaye, Bruce Cleland, Josephine Chow, Michael Suranyi

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Abstract

The following case reports are of two patients who have developed hypersensitivity reactions to the red cell growth hormones, darbepoietin and erythropoietin. The subsequent skin testing and clinical course suggested that the cause of these reactions was due to the excipient polysorbate 80. This finding might have implications in the recent increase in the incidence of pure red cell aplasia.

Original language	English
Pages (from-to)	317-320
Number of pages	4
Journal	Nephrology
Volume	10
Issue number	3
DOIs	https://doi.org/10.1111/j.1440-1797.2005.00389.x
Publication status	Published - Jun 2005
Externally published	Yes

Keywords

Darbepoietin
Erythropoietin
Hypersensitivity
Polysorbate

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10.1111/j.1440-1797.2005.00389.x

Cite this

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abstract = "The following case reports are of two patients who have developed hypersensitivity reactions to the red cell growth hormones, darbepoietin and erythropoietin. The subsequent skin testing and clinical course suggested that the cause of these reactions was due to the excipient polysorbate 80. This finding might have implications in the recent increase in the incidence of pure red cell aplasia.",

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AU - Chow, Josephine

AU - Suranyi, Michael

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KW - Erythropoietin

KW - Hypersensitivity

KW - Polysorbate

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ER -

Hypersensitivity reactions to the polysorbate contained in recombinant erythropoietin and darbepoietin

Abstract

Keywords

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