Impact of Uptake Period on 18F-DCFPyL-PSMA PET/CT Maximum Standardised Uptake Value

Anthony Joe Nassour; Anika Jain; Hadia Khanani; Nicholas Hui; Nadine J. Thompson; Brian Sorensen; Sris Baskaranathan; Philip Bergersen; Venu Chalasani; Thomas Dean; Max Dias; Michael Wines; James Symons; Lisa Tarlinton; Henry Woo

doi:10.3390/cancers17060960

Impact of Uptake Period on ¹⁸F-DCFPyL-PSMA PET/CT Maximum Standardised Uptake Value

Anthony Joe Nassour
, Anika Jain
, Hadia Khanani
, Nicholas Hui
, Nadine J. Thompson
, Brian Sorensen
, Sris Baskaranathan
, Philip Bergersen
, Venu Chalasani
, Thomas Dean
, Max Dias
, Michael Wines
, James Symons
, Lisa Tarlinton
, Henry Woo

School of Medicine

Sydney Adventist Hospital
I-MED Radiology
Department of Urology
Blacktown Hospital

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The accuracy of PSMA PET imaging can be influenced by the time between the injection of the imaging agent and when the scan is taken. This study explored how different time intervals (60, 90 and 120 min) affect the measurement of SUV_max, a key value used in diagnosing prostate cancer. The results showed that longer times consistently led to higher SUV_max values, with the most significant change seen between 60 and 120 min. These findings suggest that waiting 120 min before scanning may provide the most accurate results for this type of imaging. Additional research is needed to confirm if this timing is effective for other similar imaging methods.

Original language	English
Article number	960
Journal	Cancers
Volume	17
Issue number	6
DOIs	https://doi.org/10.3390/cancers17060960
Publication status	Published - Mar 2025

Bibliographical note

Publisher Copyright:
© 2025 by the authors.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

prostate cancer
PSMA PET/CT
standardised uptake value
uptake period
uptake time

Access to Document

10.3390/cancers17060960

Cite this

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title = "Impact of Uptake Period on 18F-DCFPyL-PSMA PET/CT Maximum Standardised Uptake Value",

abstract = "The accuracy of PSMA PET imaging can be influenced by the time between the injection of the imaging agent and when the scan is taken. This study explored how different time intervals (60, 90 and 120 min) affect the measurement of SUVmax, a key value used in diagnosing prostate cancer. The results showed that longer times consistently led to higher SUVmax values, with the most significant change seen between 60 and 120 min. These findings suggest that waiting 120 min before scanning may provide the most accurate results for this type of imaging. Additional research is needed to confirm if this timing is effective for other similar imaging methods.",

keywords = "prostate cancer, PSMA PET/CT, standardised uptake value, uptake period, uptake time",

author = "Nassour, \{Anthony Joe\} and Anika Jain and Hadia Khanani and Nicholas Hui and Thompson, \{Nadine J.\} and Brian Sorensen and Sris Baskaranathan and Philip Bergersen and Venu Chalasani and Thomas Dean and Max Dias and Michael Wines and James Symons and Lisa Tarlinton and Henry Woo",

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month = mar,

doi = "10.3390/cancers17060960",

language = "English",

volume = "17",

journal = "Cancers",

issn = "2072-6694",

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T1 - Impact of Uptake Period on 18F-DCFPyL-PSMA PET/CT Maximum Standardised Uptake Value

AU - Nassour, Anthony Joe

AU - Jain, Anika

AU - Khanani, Hadia

AU - Hui, Nicholas

AU - Thompson, Nadine J.

AU - Sorensen, Brian

AU - Baskaranathan, Sris

AU - Bergersen, Philip

AU - Chalasani, Venu

AU - Dean, Thomas

AU - Dias, Max

AU - Wines, Michael

AU - Symons, James

AU - Tarlinton, Lisa

AU - Woo, Henry

PY - 2025/3

Y1 - 2025/3

N2 - The accuracy of PSMA PET imaging can be influenced by the time between the injection of the imaging agent and when the scan is taken. This study explored how different time intervals (60, 90 and 120 min) affect the measurement of SUVmax, a key value used in diagnosing prostate cancer. The results showed that longer times consistently led to higher SUVmax values, with the most significant change seen between 60 and 120 min. These findings suggest that waiting 120 min before scanning may provide the most accurate results for this type of imaging. Additional research is needed to confirm if this timing is effective for other similar imaging methods.

AB - The accuracy of PSMA PET imaging can be influenced by the time between the injection of the imaging agent and when the scan is taken. This study explored how different time intervals (60, 90 and 120 min) affect the measurement of SUVmax, a key value used in diagnosing prostate cancer. The results showed that longer times consistently led to higher SUVmax values, with the most significant change seen between 60 and 120 min. These findings suggest that waiting 120 min before scanning may provide the most accurate results for this type of imaging. Additional research is needed to confirm if this timing is effective for other similar imaging methods.

KW - prostate cancer

KW - PSMA PET/CT

KW - standardised uptake value

KW - uptake period

KW - uptake time

UR - https://www.scopus.com/pages/publications/105001248939

U2 - 10.3390/cancers17060960

DO - 10.3390/cancers17060960

M3 - Article

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