Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor

Leon Caly, Nitin K. Saksena, Sabine C. Piller, David A. Jans

    Research output: Contribution to journalArticle

    29 Citations (Scopus)

    Abstract

    We previously reported an epidemiologically linked HIV-1 infected patient cohort in which a long term non-progressor (LTNP) infected two recipients who then exhibited normal disease progression. Expression of patient-derived vpr sequences from each of the three cohort members in mammalian cells tagged with GFP revealed a significant reduction in Vpr nuclear import and virion incorporation uniquely from the LTNP, whereas Vpr from the two progressing recipients displayed normal localisation and virion incorporation, implying a link between efficient Vpr nuclear import and HIV disease progression. Importantly, an F72L point mutation in the LTNP was identified for the first time as being uniquely responsible for decreased Vpr nuclear import.
    Original languageEnglish
    Article number67
    Number of pages8
    JournalRetrovirology
    Volume5
    DOIs
    Publication statusPublished - 2008

    Open Access - Access Right Statement

    © 2008 Caly et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Keywords

    • HIV (viruses)
    • Viral Protein R
    • epidemiology
    • infection
    • mutation

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