TY - JOUR
T1 - Increased levels of cortical serotonin 2A receptors and serotonin transporter in the CNS of neuregulin 1 hypomorphic/mutant mice
AU - Dean, Brian
AU - Karl, Tim
AU - Pavey, Geoffrey
AU - Boer, Simone
AU - Duffy, Liesl
AU - Scarr, Elizabeth
PY - 2008
Y1 - 2008
N2 - Changes in neuregulin 1 expression have been reported in the CNS from subjects with schizophrenia. As neuregulin 1 is important in cortical development we postulated that changes in neuregulin 1 expression may contribute towards changes in cholinergic, glutamatergic and serotonergic markers that are well documented in the CNS of subjects with that disorder. To begin to test this hypothesis, we used in situ radioligand binding to measure levels of muscarinic M1/M4 receptors, the kainate receptor, the NMDA receptor, the serotonin 2A receptor, the serotonin 1A receptor and the serotonin transporter in the CNS from heterozygous transmembrane domain neuregulin 1 mutant mice. The major outcomes from these studies was the demonstration of an overall increase in levels of the serotonin 2A receptor (F = 11.3, d.f. = 3,1,72, p = 0.0012) and serotonin transporter (F = 5.00, d.f. = 1,3,72, p < 0.05) in the mutant mice. Levels of the other receptors did not vary in the mutant mice compared to their wild type-like litter mates. These data are the first evidence to suggest that NRG1 gene expression may be involved in regulating the development of the serotonergic system in the mammalian CNS.
AB - Changes in neuregulin 1 expression have been reported in the CNS from subjects with schizophrenia. As neuregulin 1 is important in cortical development we postulated that changes in neuregulin 1 expression may contribute towards changes in cholinergic, glutamatergic and serotonergic markers that are well documented in the CNS of subjects with that disorder. To begin to test this hypothesis, we used in situ radioligand binding to measure levels of muscarinic M1/M4 receptors, the kainate receptor, the NMDA receptor, the serotonin 2A receptor, the serotonin 1A receptor and the serotonin transporter in the CNS from heterozygous transmembrane domain neuregulin 1 mutant mice. The major outcomes from these studies was the demonstration of an overall increase in levels of the serotonin 2A receptor (F = 11.3, d.f. = 3,1,72, p = 0.0012) and serotonin transporter (F = 5.00, d.f. = 1,3,72, p < 0.05) in the mutant mice. Levels of the other receptors did not vary in the mutant mice compared to their wild type-like litter mates. These data are the first evidence to suggest that NRG1 gene expression may be involved in regulating the development of the serotonergic system in the mammalian CNS.
KW - mice as laboratory animals
KW - schizophrenia
KW - serotonin
UR - http://handle.uws.edu.au:8081/1959.7/uws:36221
U2 - 10.1016/j.schres.2007.10.013
DO - 10.1016/j.schres.2007.10.013
M3 - Article
SN - 1573-2509
SN - 0920-9964
VL - 99
SP - 341
EP - 349
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1
ER -