Induction of circulating group II phospholipase A2 expression in adults with malaria

P. Vadas; J. Keystone; E. Stefanski; K. Scott; W. Pruzanski

Induction of circulating group II phospholipase A2 expression in adults with malaria

P. Vadas, J. Keystone, E. Stefanski, K. Scott, W. Pruzanski

University of Toronto

Research output: Contribution to journal › Comment/debate

30 Citations (Scopus)

Abstract

High levels of interleukin 1 and tumor necrosis factor are found in both cases of malaria and cases of septic shock. Since both interleukin 1 and tumor necrosis factor induce expression of the proinflammatory enzyme phospholipase A2 (PLA2), we examined serum PLA2 levels in 14 adults with malaria. Mean serum PLA2 activity was elevated 40-fold above normal (P < 0.001). Serum PLA2 activity correlated with PLA2 immunoreactivity (r = 0.987; P < 0.001) by an enzyme-linked immunosorbent assay specific for human group II PLA2, showing that serum PLA2 in cases of malaria is host derived. This article describes the novel finding of elevated PLA2 levels in cases of malaria, further strengthening the notion that mediators of the host response in cases of malaria are similar to those in cases of septic shock.

Original language	English
Pages (from-to)	3928-3931
Number of pages	4
Journal	Infection and Immunity
Volume	60
Issue number	9
Publication status	Published - 1992
Externally published	Yes

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title = "Induction of circulating group II phospholipase A2 expression in adults with malaria",

abstract = "High levels of interleukin 1 and tumor necrosis factor are found in both cases of malaria and cases of septic shock. Since both interleukin 1 and tumor necrosis factor induce expression of the proinflammatory enzyme phospholipase A2 (PLA2), we examined serum PLA2 levels in 14 adults with malaria. Mean serum PLA2 activity was elevated 40-fold above normal (P < 0.001). Serum PLA2 activity correlated with PLA2 immunoreactivity (r = 0.987; P < 0.001) by an enzyme-linked immunosorbent assay specific for human group II PLA2, showing that serum PLA2 in cases of malaria is host derived. This article describes the novel finding of elevated PLA2 levels in cases of malaria, further strengthening the notion that mediators of the host response in cases of malaria are similar to those in cases of septic shock.",

author = "P. Vadas and J. Keystone and E. Stefanski and K. Scott and W. Pruzanski",

year = "1992",

language = "English",

volume = "60",

pages = "3928--3931",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "9",

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TY - JOUR

T1 - Induction of circulating group II phospholipase A2 expression in adults with malaria

AU - Vadas, P.

AU - Keystone, J.

AU - Stefanski, E.

AU - Scott, K.

AU - Pruzanski, W.

PY - 1992

Y1 - 1992

N2 - High levels of interleukin 1 and tumor necrosis factor are found in both cases of malaria and cases of septic shock. Since both interleukin 1 and tumor necrosis factor induce expression of the proinflammatory enzyme phospholipase A2 (PLA2), we examined serum PLA2 levels in 14 adults with malaria. Mean serum PLA2 activity was elevated 40-fold above normal (P < 0.001). Serum PLA2 activity correlated with PLA2 immunoreactivity (r = 0.987; P < 0.001) by an enzyme-linked immunosorbent assay specific for human group II PLA2, showing that serum PLA2 in cases of malaria is host derived. This article describes the novel finding of elevated PLA2 levels in cases of malaria, further strengthening the notion that mediators of the host response in cases of malaria are similar to those in cases of septic shock.

AB - High levels of interleukin 1 and tumor necrosis factor are found in both cases of malaria and cases of septic shock. Since both interleukin 1 and tumor necrosis factor induce expression of the proinflammatory enzyme phospholipase A2 (PLA2), we examined serum PLA2 levels in 14 adults with malaria. Mean serum PLA2 activity was elevated 40-fold above normal (P < 0.001). Serum PLA2 activity correlated with PLA2 immunoreactivity (r = 0.987; P < 0.001) by an enzyme-linked immunosorbent assay specific for human group II PLA2, showing that serum PLA2 in cases of malaria is host derived. This article describes the novel finding of elevated PLA2 levels in cases of malaria, further strengthening the notion that mediators of the host response in cases of malaria are similar to those in cases of septic shock.

UR - http://www.scopus.com/inward/record.url?scp=0026782942&partnerID=8YFLogxK

M3 - Comment/debate

C2 - 1500203

AN - SCOPUS:0026782942

SN - 0019-9567

VL - 60

SP - 3928

EP - 3931

JO - Infection and Immunity

JF - Infection and Immunity

IS - 9

ER -

Induction of circulating group II phospholipase A2 expression in adults with malaria

Abstract

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